Abstract
Enterovirus D68 (EV-D68) was detected in 93 patients from five European countries between 1 January 2019 and 15 January 2020, a season with expected low circulation. Patients were primarily children (n = 67, median age: 4 years), 59 patients required hospitalisation and five had severe neurologic manifestations. Phylogenetic analysis revealed two clusters in the B3 subclade and subclade A2/D. This circulation of EV-D68 associated with neurological manifestations stresses the importance of surveillance and diagnostics beyond expected peak years.
Keywords:
acute flaccid myelitis; enterovirus D68; novel strains; severe respiratory infection; surveillance.
MeSH terms
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Child
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Child, Preschool
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Disease Outbreaks*
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Enterovirus D, Human / classification
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Enterovirus D, Human / genetics*
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Enterovirus D, Human / isolation & purification*
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Enterovirus Infections / diagnosis*
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Enterovirus Infections / epidemiology
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Enterovirus Infections / virology*
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Europe / epidemiology
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Female
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Humans
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Infant
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Infant, Newborn
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Male
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Middle Aged
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Nervous System Diseases / complications*
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Nervous System Diseases / epidemiology
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Phylogeny
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Polymerase Chain Reaction
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Population Surveillance
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Prevalence
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Respiratory Tract Infections / epidemiology
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Respiratory Tract Infections / physiopathology
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Respiratory Tract Infections / virology*
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Seasons
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Young Adult