My Bibliography

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Nasehi R, Schieren J, Grannemann C, Palkowitz AL, Babendreyer A, Schwarz N, Aveic S, Ludwig A, Leube RE, Fischer H. Bioprinting-associated pulsatile hydrostatic pressure elicits a mild proinflammatory response in epi- and endothelial cells. Biomater Adv. 2023 Apr;147:213329. doi: 10.1016/j.bioadv.2023.213329. Epub 2023 Feb 8. PubMed PMID: 36801795.

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Cheremkhina M, Klein S, Babendreyer A, Ludwig A, Schmitz-Rode T, Jockenhoevel S, Cornelissen CG, Thiebes AL. Influence of Aerosolization on Endothelial Cells for Efficient Cell Deposition in Biohybrid and Regenerative Applications. Micromachines (Basel). 2023 Feb 28;14(3). doi: 10.3390/mi14030575. PubMed PMID: 36984982; PubMed Central PMCID: PMC10053765.

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van der Vorst EPC, Maas SL, Theodorou K, Peters LJF, Jin H, Rademakers T, Gijbels MJ, Rousch M, Jansen Y, Weber C, Lehrke M, Lebherz C, Yildiz D, Ludwig A, Bentzon JF, Biessen EAL, Donners MMPC. Endothelial ADAM10 controls cellular response to oxLDL and its deficiency exacerbates atherosclerosis with intraplaque hemorrhage and neovascularization in mice. Front Cardiovasc Med. 2023;10:974918. doi: 10.3389/fcvm.2023.974918. eCollection 2023. PubMed PMID: 36776254; PubMed Central PMCID: PMC9911417.

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Xiao W, Pinilla-Baquero A, Faulkner J, Song X, Prabhakar P, Qiu H, Moremen KW, Ludwig A, Dempsey PJ, Azadi P, Wang L. Robo4 is constitutively shed by ADAMs from endothelial cells and the shed Robo4 functions to inhibit Slit3-induced angiogenesis. Sci Rep. 2022 Mar 14;12(1):4352. doi: 10.1038/s41598-022-08227-8. PubMed PMID: 35288626; PubMed Central PMCID: PMC8921330.

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Niehues RV, Wozniak J, Wiersch F, Lilienthal E, Tacken N, Schumertl T, Garbers C, Ludwig A, Düsterhöft S. The collectrin-like part of the SARS-CoV-1 and -2 receptor ACE2 is shed by the metalloproteinases ADAM10 and ADAM17. FASEB J. 2022 Mar;36(3):e22234. doi: 10.1096/fj.202101521R. PubMed PMID: 35199397; PubMed Central PMCID: PMC9111296.

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Giese AA, Babendreyer A, Krappen P, Gross A, Strnad P, Düsterhöft S, Ludwig A. Inflammatory activation of surface molecule shedding by upregulation of the pseudoprotease iRhom2 in colon epithelial cells. Sci Rep. 2021 Dec 20;11(1):24230. doi: 10.1038/s41598-021-03522-2. PubMed PMID: 34930929; PubMed Central PMCID: PMC8688420.

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Diener N, Fontaine JF, Klein M, Hieronymus T, Wanke F, Kurschus FC, Ludwig A, Ware C, Saftig P, Bopp T, Clausen BE, Backer RA. Posttranslational modifications by ADAM10 shape myeloid antigen-presenting cell homeostasis in the splenic marginal zone. Proc Natl Acad Sci U S A. 2021 Sep 21;118(38). doi: 10.1073/pnas.2111234118. PubMed PMID: 34526403; PubMed Central PMCID: PMC8463803.

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Jain P, Nishiguchi A, Linz G, Wessling M, Ludwig A, Rossaint R, Möller M, Singh S. Reconstruction of Ultra-thin Alveolar-capillary Basement Membrane Mimics. Adv Biol (Weinh). 2021 Aug;5(8):e2000427. doi: 10.1002/adbi.202000427. Epub 2021 May 13. PubMed PMID: 33987968.

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Wozniak J, Floege J, Ostendorf T, Ludwig A. Key metalloproteinase-mediated pathways in the kidney. Nat Rev Nephrol. 2021 Aug;17(8):513-527. doi: 10.1038/s41581-021-00415-5. Epub 2021 Apr 20. Review. PubMed PMID: 33879883.

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Düsterhöft S, Kahveci-Türköz S, Wozniak J, Seifert A, Kasparek P, Ohm H, Liu S, Kopkanova J, Lokau J, Garbers C, Preisinger C, Sedlacek R, Freeman M, Ludwig A. The iRhom homology domain is indispensable for ADAM17-mediated TNFα and EGF receptor ligand release. Cell Mol Life Sci. 2021 Jun;78(11):5015-5040. doi: 10.1007/s00018-021-03845-3. Epub 2021 May 5. PubMed PMID: 33950315; PubMed Central PMCID: PMC8233286.

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Gasterich N, Wetz S, Tillmann S, Fein L, Seifert A, Slowik A, Weiskirchen R, Zendedel A, Ludwig A, Koschmieder S, Beyer C, Clarner T. Inflammatory Responses of Astrocytes Are Independent from Lipocalin 2. J Mol Neurosci. 2021 May;71(5):933-942. doi: 10.1007/s12031-020-01712-7. Epub 2020 Sep 21. PubMed PMID: 32959226.

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Awan T, Babendreyer A, Wozniak J, Alvi AM, Sterzer V, Cook L, Bartsch JW, Liedtke C, Yildiz D, Ludwig A. Expression of the Metalloproteinase ADAM8 Is Upregulated in Liver Inflammation Models and Enhances Cytokine Release In Vitro. Mediators Inflamm. 2021;2021:6665028. doi: 10.1155/2021/6665028. eCollection 2021. PubMed PMID: 33814981; PubMed Central PMCID: PMC7987468.

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Awan T, Babendreyer A, Mahmood Alvi A, Düsterhöft S, Lambertz D, Bartsch JW, Liedtke C, Ludwig A. Expression levels of the metalloproteinase ADAM8 critically regulate proliferation, migration and malignant signalling events in hepatoma cells. J Cell Mol Med. 2021 Feb;25(4):1982-1999. doi: 10.1111/jcmm.16015. Epub 2020 Dec 13. PubMed PMID: 33314720; PubMed Central PMCID: PMC7882935.

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Seifert A, Düsterhöft S, Wozniak J, Koo CZ, Tomlinson MG, Nuti E, Rossello A, Cuffaro D, Yildiz D, Ludwig A. The metalloproteinase ADAM10 requires its activity to sustain surface expression. Cell Mol Life Sci. 2021 Jan;78(2):715-732. doi: 10.1007/s00018-020-03507-w. Epub 2020 May 5. PubMed PMID: 32372373; PubMed Central PMCID: PMC7873107.

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Babendreyer A, Ludwig A. Mechanic Forces Promote Brain Endothelial Activation by SARS-CoV-2 Spike Protein. Stroke. 2021 Jan;52(1):271-273. doi: 10.1161/STROKEAHA.120.033119. Epub 2020 Nov 9. PubMed PMID: 33161848.

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Babendreyer A, Rojas-González DM, Giese AA, Fellendorf S, Düsterhöft S, Mela P, Ludwig A. Differential Induction of the ADAM17 Regulators iRhom1 and 2 in Endothelial Cells. Front Cardiovasc Med. 2020;7:610344. doi: 10.3389/fcvm.2020.610344. eCollection 2020. PubMed PMID: 33335915; PubMed Central PMCID: PMC7736406.

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Seifert A, Wozniak J, Düsterhöft S, Kasparek P, Sedlacek R, Dreschers S, Orlikowsky TW, Yildiz D, Ludwig A. The iRhom2/ADAM17 Axis Attenuates Bacterial Uptake by Phagocytes in a Cell Autonomous Manner. Int J Mol Sci. 2020 Aug 19;21(17). doi: 10.3390/ijms21175978. PubMed PMID: 32825187; PubMed Central PMCID: PMC7503280.

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Kajanova I, Zatovicova M, Jelenska L, Sedlakova O, Barathova M, Csaderova L, Debreova M, Lukacikova L, Grossmannova K, Labudova M, Golias T, Svastova E, Ludwig A, Muller P, Vojtesek B, Pastorek J, Pastorekova S. Impairment of carbonic anhydrase IX ectodomain cleavage reinforces tumorigenic and metastatic phenotype of cancer cells. Br J Cancer. 2020 May;122(11):1590-1603. doi: 10.1038/s41416-020-0804-z. Epub 2020 Mar 25. PubMed PMID: 32210366; PubMed Central PMCID: PMC7250822.

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Platen C, Dreschers S, Wappler J, Ludwig A, Düsterhöft S, Reiss LK, Orlikowsky TW. Amphiregulin Regulates Phagocytosis-Induced Cell Death in Monocytes via EGFR and the Bcl-2 Protein Family. Mediators Inflamm. 2019;2019:1603131. doi: 10.1155/2019/1603131. eCollection 2019. PubMed PMID: 32082070; PubMed Central PMCID: PMC7012211.

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Düsterhöft S, Babendreyer A, Giese AA, Flasshove C, Ludwig A. Status update on iRhom and ADAM17: It's still complicated. Biochim Biophys Acta Mol Cell Res. 2019 Oct;1866(10):1567-1583. doi: 10.1016/j.bbamcr.2019.06.017. Epub 2019 Jul 19. Review. PubMed PMID: 31330158.

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Babendreyer A, Molls L, Simons IM, Dreymueller D, Biller K, Jahr H, Denecke B, Boon RA, Bette S, Schnakenberg U, Ludwig A. The metalloproteinase ADAM15 is upregulated by shear stress and promotes survival of endothelial cells. J Mol Cell Cardiol. 2019 Sep;134:51-61. doi: 10.1016/j.yjmcc.2019.06.017. Epub 2019 Jul 1. PubMed PMID: 31271758.

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Krabbe J, Ruske N, Kanzler S, Reiss LK, Ludwig A, Uhlig S, Martin C. Retrograde perfusion in isolated perfused mouse lungs-Feasibility and effects on cytokine levels and pulmonary oedema formation. Basic Clin Pharmacol Toxicol. 2019 Sep;125(3):279-288. doi: 10.1111/bcpt.13236. Epub 2019 Apr 21. PubMed PMID: 30925204.

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Schick D, Babendreyer A, Wozniak J, Awan T, Noels H, Liehn E, Bartsch JW, Vlacil AK, Grote K, Zayat R, Goetzenich A, Ludwig A, Dreymueller D. Elevated expression of the metalloproteinase ADAM8 associates with vascular diseases in mice and humans. Atherosclerosis. 2019 Jul;286:163-171. doi: 10.1016/j.atherosclerosis.2019.03.008. Epub 2019 Mar 17. PubMed PMID: 30910225.

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Sépult C, Bellefroid M, Rocks N, Donati K, Gérard C, Gilles C, Ludwig A, Duysinx B, Noël A, Cataldo D. ADAM10 mediates malignant pleural mesothelioma invasiveness. Oncogene. 2019 May;38(18):3521-3534. doi: 10.1038/s41388-018-0669-2. Epub 2019 Jan 16. PubMed PMID: 30651596; PubMed Central PMCID: PMC6756017.

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Dreschers S, Platen C, Ludwig A, Gille C, Köstlin N, Orlikowsky TW. Metalloproteinases TACE and MMP-9 Differentially Regulate Death Factors on Adult and Neonatal Monocytes After Infection with Escherichia coli. Int J Mol Sci. 2019 Mar 20;20(6). doi: 10.3390/ijms20061399. PubMed PMID: 30897723; PubMed Central PMCID: PMC6471605.

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Wozniak J, Ludwig A. Novel role of APP cleavage by ADAM10 for breast cancer metastasis. EBioMedicine. 2018 Dec;38:5-6. doi: 10.1016/j.ebiom.2018.11.050. Epub 2018 Nov 29. PubMed PMID: 30503863; PubMed Central PMCID: PMC6306391.

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Conrad C, Götte M, Schlomann U, Roessler M, Pagenstecher A, Anderson P, Preston J, Pruessmeyer J, Ludwig A, Li R, Kamm RD, Ritz R, Carl B, Nimsky C, Bartsch JW. ADAM8 expression in breast cancer derived brain metastases: Functional implications on MMP-9 expression and transendothelial migration in breast cancer cells. Int J Cancer. 2018 Feb 15;142(4):779-791. doi: 10.1002/ijc.31090. Epub 2017 Oct 31. PubMed PMID: 28986926.

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Theodorou K, van der Vorst EPC, Gijbels MJ, Wolfs IMJ, Jeurissen M, Theelen TL, Sluimer JC, Wijnands E, Cleutjens JP, Li Y, Jansen Y, Weber C, Ludwig A, Bentzon JF, Bartsch JW, Biessen EAL, Donners MMPC. Whole body and hematopoietic ADAM8 deficiency does not influence advanced atherosclerotic lesion development, despite its association with human plaque progression. Sci Rep. 2017 Sep 15;7(1):11670. doi: 10.1038/s41598-017-10549-x. PubMed PMID: 28916789; PubMed Central PMCID: PMC5601942.

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Dreymueller D, Ludwig A. Considerations on inhibition approaches for proinflammatory functions of ADAM proteases. Platelets. 2017 Jun;28(4):354-361. doi: 10.1080/09537104.2016.1203396. Epub 2016 Jul 26. Review. PubMed PMID: 27460023.

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Koenen A, Babendreyer A, Schumacher J, Pasqualon T, Schwarz N, Seifert A, Deupi X, Ludwig A, Dreymueller D. The DRF motif of CXCR6 as chemokine receptor adaptation to adhesion. PLoS One. 2017;12(3):e0173486. doi: 10.1371/journal.pone.0173486. eCollection 2017. PubMed PMID: 28267793; PubMed Central PMCID: PMC5340378.

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Taggart C, Mall MA, Lalmanach G, Cataldo D, Ludwig A, Janciauskiene S, Heath N, Meiners S, Overall CM, Schultz C, Turk B, Borensztajn KS. Protean proteases: at the cutting edge of lung diseases. Eur Respir J. 2017 Feb;49(2). doi: 10.1183/13993003.01200-2015. Print 2017 Feb. Review. PubMed PMID: 28179435.

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Dreymueller D, Theodorou K, Donners M, Ludwig A. Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases. Mediators Inflamm. 2017;2017:9621724. doi: 10.1155/2017/9621724. Epub 2017 Feb 5. Review. PubMed PMID: 28260841; PubMed Central PMCID: PMC5316459.

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Groth E, Pruessmeyer J, Babendreyer A, Schumacher J, Pasqualon T, Dreymueller D, Higashiyama S, Lorenzen I, Grötzinger J, Cataldo D, Ludwig A. Stimulated release and functional activity of surface expressed metalloproteinase ADAM17 in exosomes. Biochim Biophys Acta. 2016 Nov;1863(11):2795-2808. doi: 10.1016/j.bbamcr.2016.09.002. Epub 2016 Sep 4. PubMed PMID: 27599715.

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Pasqualon T, Lue H, Groening S, Pruessmeyer J, Jahr H, Denecke B, Bernhagen J, Ludwig A. Cell surface syndecan-1 contributes to binding and function of macrophage migration inhibitory factor (MIF) on epithelial tumor cells. Biochim Biophys Acta. 2016 Apr;1863(4):717-26. doi: 10.1016/j.bbamcr.2016.02.003. Epub 2016 Feb 4. PubMed PMID: 26852939.

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Kuhn PH, Colombo AV, Schusser B, Dreymueller D, Wetzel S, Schepers U, Herber J, Ludwig A, Kremmer E, Montag D, Müller U, Schweizer M, Saftig P, Bräse S, Lichtenthaler SF. Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function. Elife. 2016 Jan 23;5. doi: 10.7554/eLife.12748. PubMed PMID: 26802628; PubMed Central PMCID: PMC4786429.

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Hattermann K, Gebhardt H, Krossa S, Ludwig A, Lucius R, Held-Feindt J, Mentlein R. Transmembrane chemokines act as receptors in a novel mechanism termed inverse signaling. Elife. 2016 Jan 21;5:e10820. doi: 10.7554/eLife.10820. PubMed PMID: 26796342; PubMed Central PMCID: PMC4739769.

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Dreymueller D, Goetzenich A, Emontzpohl C, Soppert J, Ludwig A, Stoppe C. The perioperative time course and clinical significance of the chemokine CXCL16 in patients undergoing cardiac surgery. J Cell Mol Med. 2016 Jan;20(1):104-15. doi: 10.1111/jcmm.12708. Epub 2015 Oct 23. PubMed PMID: 26499307; PubMed Central PMCID: PMC4717864.

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Schneider KM, Bieghs V, Heymann F, Hu W, Dreymueller D, Liao L, Frissen M, Ludwig A, Gassler N, Pabst O, Latz E, Sellge G, Penders J, Tacke F, Trautwein C. CX3CR1 is a gatekeeper for intestinal barrier integrity in mice: Limiting steatohepatitis by maintaining intestinal homeostasis. Hepatology. 2015 Nov;62(5):1405-16. doi: 10.1002/hep.27982. Epub 2015 Sep 2. PubMed PMID: 26178698.

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Pasqualon T, Pruessmeyer J, Jankowski V, Babendreyer A, Groth E, Schumacher J, Koenen A, Weidenfeld S, Schwarz N, Denecke B, Jahr H, Dreymueller D, Jankowski J, Ludwig A. A cytoplasmic C-terminal fragment of Syndecan-1 is generated by sequential proteolysis and antagonizes Syndecan-1 dependent lung tumor cell migration. Oncotarget. 2015 Oct 13;6(31):31295-312. doi: 10.18632/oncotarget.5174. PubMed PMID: 26378057; PubMed Central PMCID: PMC4741606.

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Pasqualon T, Pruessmeyer J, Weidenfeld S, Babendreyer A, Groth E, Schumacher J, Schwarz N, Denecke B, Jahr H, Zimmermann P, Dreymueller D, Ludwig A. A transmembrane C-terminal fragment of syndecan-1 is generated by the metalloproteinase ADAM17 and promotes lung epithelial tumor cell migration and lung metastasis formation. Cell Mol Life Sci. 2015 Oct;72(19):3783-801. doi: 10.1007/s00018-015-1912-4. Epub 2015 Apr 26. PubMed PMID: 25912030.

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Knapinska AM, Dreymuller D, Ludwig A, Smith L, Golubkov V, Sohail A, Fridman R, Giulianotti M, LaVoi TM, Houghten RA, Fields GB, Minond D. SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes. J Med Chem. 2015 Aug 13;58(15):5808-24. doi: 10.1021/acs.jmedchem.5b00354. Epub 2015 Aug 4. PubMed PMID: 26192023; PubMed Central PMCID: PMC5420329.

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van der Vorst EP, Jeurissen M, Wolfs IM, Keijbeck A, Theodorou K, Wijnands E, Schurgers L, Weber S, Gijbels MJ, Hamers AA, Dreymueller D, Rose-John S, de Winther MP, Ludwig A, Saftig P, Biessen EA, Donners MM. Myeloid A disintegrin and metalloproteinase domain 10 deficiency modulates atherosclerotic plaque composition by shifting the balance from inflammation toward fibrosis. Am J Pathol. 2015 Apr;185(4):1145-55. doi: 10.1016/j.ajpath.2014.11.028. Epub 2015 Feb 7. PubMed PMID: 25659879.

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Dreymueller D, Uhlig S, Ludwig A. ADAM-family metalloproteinases in lung inflammation: potential therapeutic targets. Am J Physiol Lung Cell Mol Physiol. 2015 Feb 15;308(4):L325-43. doi: 10.1152/ajplung.00294.2014. Epub 2014 Dec 5. Review. PubMed PMID: 25480335.

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Shimoda M, Principe S, Jackson HW, Luga V, Fang H, Molyneux SD, Shao YW, Aiken A, Waterhouse PD, Karamboulas C, Hess FM, Ohtsuka T, Okada Y, Ailles L, Ludwig A, Wrana JL, Kislinger T, Khokha R. Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state. Nat Cell Biol. 2014 Sep;16(9):889-901. doi: 10.1038/ncb3021. Epub 2014 Aug 24. PubMed PMID: 25150980.

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Pruessmeyer J, Hess FM, Alert H, Groth E, Pasqualon T, Schwarz N, Nyamoya S, Kollert J, van der Vorst E, Donners M, Martin C, Uhlig S, Saftig P, Dreymueller D, Ludwig A. Leukocytes require ADAM10 but not ADAM17 for their migration and inflammatory recruitment into the alveolar space. Blood. 2014 Jun 26;123(26):4077-88. doi: 10.1182/blood-2013-09-511543. Epub 2014 May 15. PubMed PMID: 24833351.

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Romi E, Gokhman I, Wong E, Antonovsky N, Ludwig A, Sagi I, Saftig P, Tessier-Lavigne M, Yaron A. ADAM metalloproteases promote a developmental switch in responsiveness to the axonal repellant Sema3A. Nat Commun. 2014 Jun 5;5:4058. doi: 10.1038/ncomms5058. PubMed PMID: 24898499.

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Herzog C, Haun RS, Ludwig A, Shah SV, Kaushal GP. ADAM10 is the major sheddase responsible for the release of membrane-associated meprin A. J Biol Chem. 2014 May 9;289(19):13308-22. doi: 10.1074/jbc.M114.559088. Epub 2014 Mar 24. PubMed PMID: 24662289; PubMed Central PMCID: PMC4036340.

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Dreymueller D, Martin C, Schumacher J, Groth E, Boehm JK, Reiss LK, Uhlig S, Ludwig A. Smooth muscle cells relay acute pulmonary inflammation via distinct ADAM17/ErbB axes. J Immunol. 2014 Jan 15;192(2):722-31. doi: 10.4049/jimmunol.1302496. Epub 2013 Dec 16. PubMed PMID: 24342803.

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Habib P, Dreymueller D, Ludwig A, Beyer C, Dang J. Sex steroid hormone-mediated functional regulation of microglia-like BV-2 cells during hypoxia. J Steroid Biochem Mol Biol. 2013 Nov;138:195-205. doi: 10.1016/j.jsbmb.2013.06.003. Epub 2013 Jun 20. PubMed PMID: 23792783.

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Hattermann K, Held-Feindt J, Ludwig A, Mentlein R. The CXCL16-CXCR6 chemokine axis in glial tumors. J Neuroimmunol. 2013 Jul 15;260(1-2):47-54. doi: 10.1016/j.jneuroim.2013.04.006. Epub 2013 Apr 28. PubMed PMID: 23628207.