The University of Queensland

Visualizing endocytic recycling and trafficking in live neurons by subdiffractional tracking of internalized molecules

Joensuu, Merja, Martinez-Marmol, Ramon, Padmanabhan, Pranesh, Glass, Nick R., Durisic, Nela, Pelekanos, Matthew, Mollazade, Mahdie, Balistreri, Giuseppe, Amor, Rumelo, Cooper-White, Justin J., Goodhill, Geoffrey J. and Meunier, Frederic A. (2017). Visualizing endocytic recycling and trafficking in live neurons by subdiffractional tracking of internalized molecules. Nature Protocols, 12 (12), 2590-2622. doi: 10.1038/nprot.2017.116

In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters

Bademosi, Adekunle T., Lauwers, Elsa, Padmanabhan, Pranesh, Odierna, Lorenzo, Chai, Ye Jin, Papadopulos, Andreas, Goodhill, Geoffrey J., Verstreken, Patrik, Van Swinderen, Bruno and Meunier, Frederic A. (2016). In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters. Nature Communications, 7 (1) 13660, 13660. doi: 10.1038/ncomms13660

The Munc18-1 domain 3a hinge-loop controls syntaxin-1A nanodomain assembly and engagement with the SNARE complex during secretory vesicle priming

Kasula, Ravikiran, Chai, Ye Jin, Bademosi, Adekunle T., Harper, Callista B., Gormal, Rachel S., Morrow, Isabel C., Hosy, Eric, Collins, Brett M., Choquet, Daniel, Papadopulos, Andreas and Meunier, Frederic A. (2016). The Munc18-1 domain 3a hinge-loop controls syntaxin-1A nanodomain assembly and engagement with the SNARE complex during secretory vesicle priming. The Journal of Cell Biology, 214 (7) 847, 847-858. doi: 10.1083/jcb.201508118

Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregation

Chai, Ye Jin, Sierecki, Emma, Tomatis, Vanesa M., Gormal, Rachel S., Giles, Nichole, Morrow, Isabel C., Xia, Di, Götz, Jürgen, Parton, Robert G., Collins, Brett M., Gambin, Yann and Meunier, Frédéric A. (2016). Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregation. The Journal of Cell Biology, 214 (6) 705, 705-718. doi: 10.1083/jcb.201512016

Functional Roles of UNC-13/Munc13 and UNC-18/Munc18 in Neurotransmission

Meunier, Frédéric A. and Hu, Zhitao (2023). Functional Roles of UNC-13/Munc13 and UNC-18/Munc18 in Neurotransmission. Advances in Neurobiology. (pp. 203-231) Cham: Springer. doi: 10.1007/978-3-031-34229-5_8

Lipids and Secretory Vesicle Exocytosis

Akefe, Isaac O., Osborne, Shona L., Matthews, Benjamin, Wallis, Tristan P. and Meunier, Frédéric A. (2023). Lipids and Secretory Vesicle Exocytosis. Advances in Neurobiology. (pp. 357-397) Cham, Switzerland: Springer. doi: 10.1007/978-3-031-34229-5_14

Unveiling the nanoscale dynamics of the exocytic machinery in chromaffin cells with single-molecule imaging

Bademosi, Adekunle T. and Meunier, Frédéric A (2022). Unveiling the nanoscale dynamics of the exocytic machinery in chromaffin cells with single-molecule imaging. Chromaffin Cells. (pp. 311-327) edited by Ricardo Borges. New York, NY USA: Humana New York. doi: 10.1007/978-1-0716-2671-9_21

Live-cell superresolution imaging of retrograde axonal trafficking using pulse–chase labeling in cultured hippocampal neurons

Wang, Tong and Meunier, Frédéric A. (2022). Live-cell superresolution imaging of retrograde axonal trafficking using pulse–chase labeling in cultured hippocampal neurons. Membrane trafficking: methods and protocols. (pp. 101-128) edited by Jingshi Shen. New York, NY, United States: Humana/Springer Nature. doi: 10.1007/978-1-0716-2209-4_9

Combining single molecule super-resolution imaging techniques to unravel the nanoscale organization of the presynapse

Small, Christopher, Martínez-Mármol, Ramon, Amor, Rumelo, Meunier, Frederic A. and Joensuu, Merja (2021). Combining single molecule super-resolution imaging techniques to unravel the nanoscale organization of the presynapse. Exocytosis and endocytosis: methods and protocols. (pp. 265-286) edited by Florence Niedergang, Nicolas Vitale and Stéphane Gasman. New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-1044-2_18

Single-molecule imaging of recycling synaptic vesicles in live neurons

Joensuu, Merja, Martínez-Mármol, Ramon, Mollazade, Mahdie, Padmanabhan, Pranesh and Meunier, Frédéric A. (2020). Single-molecule imaging of recycling synaptic vesicles in live neurons. Single molecule microscopy in neurobiology. (pp. 81-114) edited by Nobuhiko Yamamoto and Yasushi Okada. New York, NY United States: Humana Press. doi: 10.1007/978-1-0716-0532-5_5

New developments in free fatty acids and lysophospholipids: decoding the role of phospholipases in exocytosis

Narayana, Vinod K., Kvaskoff, David and Meunier, Frederic A. (2017). New developments in free fatty acids and lysophospholipids: decoding the role of phospholipases in exocytosis. Lipidomics of stem cells. (pp. 191-206) edited by Alice Pebay and Raymond C.B. Wong. Cham, Switerland: Spinger Nature.

Exploiting endocytic pathways to prevent bacterial toxin infection

Harper, Callista B., McCluskey, Adam, Robinson, Phillip J. and Meunier, Frederic A. (2015). Exploiting endocytic pathways to prevent bacterial toxin infection. The comprehensive sourcebook of bacterial protein toxins. (pp. 1072-1094) edited by Daniel Ladant, Michel R. Popoff and Joseph E. Alouf . Amsterdam, Netherlands: Elsevier. doi: 10.1016/B978-0-12-800188-2.00040-9

Phosphoinositides in neuroexocytosis and neuronal diseases

Wen, Peter J., Osborne, Shona L. and Meunier, Frederic A. (2012). Phosphoinositides in neuroexocytosis and neuronal diseases. Current topics in microbiology and immunology. (pp. 87-98) edited by Marco Falasca and Peter K. Vogt. Amsterdam, Netherlands: Springer. doi: 10.1007/978-94-007-5025-8_4

Marine toxins potently affecting neurotransmitter release¹

Meunier, Frederic A., Mattei, Cesar F. and Molgo, Jordi (2009). Marine toxins potently affecting neurotransmitter release¹. Marine Toxins as Research Tools. (pp. 159-186) edited by Fusetani, Nobuhiro and Kem, William. Berlin & Heidelberg: Springer - Verlag. doi: 10.1007/978-3-540-87895-7_6

Lipids and Secretory Vesicle Exocytosis

Meunier, Frederic A. and Osborne, Shona L. (2008). Lipids and Secretory Vesicle Exocytosis. Molecular Mechanisms of Neurotransmitter Release. (pp. 239-261) edited by Wang, Zhao-Wen. United States: Springer. doi: 10.1007/978-1-59745-481-0

Synapsin 2a tetramerisation selectively controls the presynaptic nanoscale organisation of reserve synaptic vesicles

Longfield, Shanley F., Gormal, Rachel S., Feller, Matis, Parutto, Pierre, Reingruber, Jürgen, Wallis, Tristan P., Joensuu, Merja, Augustine, George J., Martínez-Mármol, Ramón, Holcman, David and Meunier, Frédéric A. (2024). Synapsin 2a tetramerisation selectively controls the presynaptic nanoscale organisation of reserve synaptic vesicles. Nature Communications, 15 (1) 2217, 1-18. doi: 10.1038/s41467-024-46256-1

The DDHD2-STXBP1 interaction mediates long-term memory via generation of saturated free fatty acids

Akefe, Isaac O, Saber, Saber H, Matthews, Benjamin, Venkatesh, Bharat G, Gormal, Rachel S, Blackmore, Daniel G, Alexander, Suzy, Sieriecki, Emma, Gambin, Yann, Bertran-Gonzalez, Jesus, Vitale, Nicolas, Humeau, Yann, Gaudin, Arnaud, Ellis, Sevannah A, Michaels, Alysee A, Xue, Mingshan, Cravatt, Benjamin, Joensuu, Merja, Wallis, Tristan P and Meunier, Frédéric A (2024). The DDHD2-STXBP1 interaction mediates long-term memory via generation of saturated free fatty acids. The EMBO Journal, 43 (4), 1-35. doi: 10.1038/s44318-024-00030-7

Location, location, location: Protein kinase nanoclustering for optimised signalling output

Gormal, Rachel S., Martinez-Marmol, Ramon, Brooks, Andrew J. and Meunier, Frédéric A. (2024). Location, location, location: Protein kinase nanoclustering for optimised signalling output. eLife, 13 ARTN e93902, 1-21. doi: 10.7554/elife.93902

BoNT-A Targets Sensitized TRPV1-Positive DRG Neurons at Therapeutic Concentrations

Syed, Parnayan, Gormal, Rachel S., Sondergaard, Birgitte, Nelson, Mariana, Broide, Ron S. and Meunier, Frédéric A. (2024). BoNT-A Targets Sensitized TRPV1-Positive DRG Neurons at Therapeutic Concentrations. Toxicon, 237 107497, 107497. doi: 10.1016/j.toxicon.2024.107497

Interrogation and validation of the interactome of neuronal Munc18-interacting Mint proteins with AlphaFold2

Weeratunga, Saroja, Gormal, Rachel S., Liu, Meihan, Eldershaw, Denaye, Livingstone, Emma K., Malapaka, Anusha, Wallis, Tristan P., Bademosi, Adekunle T., Jiang, Anmin, Healy, Michael D., Meunier, Frederic A. and Collins, Brett M. (2024). Interrogation and validation of the interactome of neuronal Munc18-interacting Mint proteins with AlphaFold2. Journal of Biological Chemistry, 300 (1) 105541, 105541. doi: 10.1016/j.jbc.2023.105541

Phospholipase Modulation of Synaptic Membrane Landscape: Driving Force Behind Memory Formation?

Wallis, Tristan P. and Meunier, Frédéric A. (2023). Phospholipase Modulation of Synaptic Membrane Landscape: Driving Force Behind Memory Formation?. Cold Spring Harbor Perspectives in Biology, a041405. doi: 10.1101/cshperspect.a041405

Dissection of alpha‐synuclein specific synaptic functions by gene editing

Madhivanan, Kayalvizhi, Parra‐Rivas, Leonardo A, Joensuu, Merja, Sanders, Shanley, Caballero‐Florán, René, Bingham, Dominic, Sharma, Rohan, Jenkins, Paul M, Leterrier, Christophe, Meunier, Frederic A and Roy, Subhojit (2023). Dissection of alpha‐synuclein specific synaptic functions by gene editing. Alzheimer's & Dementia, 19 (S24). doi: 10.1002/alz.082510

SARS-CoV-2 omicron BA.5 and XBB variants have increased neurotropic potential over BA.1 in K18-hACE2 mice and human brain organoids

Stewart, Romal, Yan, Kexin, Ellis, Sevannah A., Bishop, Cameron R., Dumenil, Troy, Tang, Bing, Nguyen, Wilson, Larcher, Thibaut, Parry, Rhys, Sng, Julian De Jun, Khromykh, Alexander A., Sullivan, Robert K. P., Lor, Mary, Meunier, Frédéric A., Rawle, Daniel J. and Suhrbier, Andreas (2023). SARS-CoV-2 omicron BA.5 and XBB variants have increased neurotropic potential over BA.1 in K18-hACE2 mice and human brain organoids. Frontiers in Microbiology, 14 1320856, 1-18. doi: 10.3389/fmicb.2023.1320856

Fear extinction is regulated by the activity of long noncoding RNAs at the synapse

Liau, Wei-Siang, Zhao, Qiongyi, Bademosi, Adekunle, Gormal, Rachel S., Gong, Hao, Marshall, Paul R., Periyakaruppiah, Ambika, Madugalle, Sachithrani U., Zajaczkowski, Esmi L., Leighton, Laura J., Ren, Haobin, Musgrove, Mason, Davies, Joshua, Rauch, Simone, He, Chuan, Dickinson, Bryan C., Li, Xiang, Wei, Wei, Meunier, Frédéric A., Fernández-Moya, Sandra M., Kiebler, Michael A., Srinivasan, Balakumar, Banerjee, Sourav, Clark, Michael, Spitale, Robert C. and Bredy, Timothy W. (2023). Fear extinction is regulated by the activity of long noncoding RNAs at the synapse. Nature Communications, 14 (1) 7616, 1-16. doi: 10.1038/s41467-023-43535-1

Tau forms synaptic nano-biomolecular condensates controlling the dynamic clustering of recycling synaptic vesicles

Longfield, Shanley F., Mollazade, Mahdie, Wallis, Tristan P., Gormal, Rachel S., Joensuu, Merja, Wark, Jesse R., van Waardenberg, Ashley J., Small, Christopher, Graham, Mark E., Meunier, Frédéric A. and Martínez-Mármol, Ramón (2023). Tau forms synaptic nano-biomolecular condensates controlling the dynamic clustering of recycling synaptic vesicles. Nature Communications, 14 (1) 7277, 1-20. doi: 10.1038/s41467-023-43130-4

SARS-CoV-2 infection and viral fusogens cause neuronal and glial fusion that compromises neuronal activity

Martínez-Mármol, Ramón, Giordano-Santini, Rosina, Kaulich, Eva, Cho, Ann-Na, Przybyla, Magdalena, Riyadh, Md Asrafuzzaman, Robinson, Emilija, Chew, Keng Yih, Amor, Rumelo, Meunier, Frédéric A., Balistreri, Giuseppe, Short, Kirsty R., Ke, Yazi D., Ittner, Lars M. and Hilliard, Massimo A. (2023). SARS-CoV-2 infection and viral fusogens cause neuronal and glial fusion that compromises neuronal activity. Science Advances, 9 (23) eadg2248, 1-15. doi: 10.1126/sciadv.adg2248

Super-resolved trajectory-derived nanoclustering analysis using spatiotemporal indexing

Wallis, Tristan P., Jiang, Anmin, Young, Kyle, Hou, Huiyi, Kudo, Kye, McCann, Alex J., Durisic, Nela, Joensuu, Merja, Oelz, Dietmar, Nguyen, Hien, Gormal, Rachel S. and Meunier, Frédéric A. (2023). Super-resolved trajectory-derived nanoclustering analysis using spatiotemporal indexing. Nature Communications, 14 (1) 3353, 1-16. doi: 10.1038/s41467-023-38866-y

Hericerin derivatives activates a pan‐neurotrophic pathway in central hippocampal neurons converging to ERK1 /2 signaling enhancing spatial memory

Martínez‐Mármol, Ramón, Chai, YeJin, Conroy, Jacinta N., Khan, Zahra, Hong, Seong‐Min, Kim, Seon Beom, Gormal, Rachel S., Lee, Dae Hee, Lee, Jae Kang, Coulson, Elizabeth J., Lee, Mi Kyeong, Kim, Sun Yeou and Meunier, Frédéric A. (2023). Hericerin derivatives activates a pan‐neurotrophic pathway in central hippocampal neurons converging to ERK1 /2 signaling enhancing spatial memory. Journal of Neurochemistry, 165 (6), 791-808. doi: 10.1111/jnc.15767

Tyrosine kinases compete for growth hormone receptor binding and regulate receptor mobility and degradation

Chhabra, Yash, Seiffert, Pernille, Gormal, Rachel S., Vullings, Manon, Lee, Christine Mei Mei, Wallis, Tristan P., Dehkhoda, Farhad, Indrakumar, Sowmya, Jacobsen, Nina L., Lindorff-Larsen, Kresten, Durisic, Nela, Waters, Michael J., Meunier, Frederic A., Kragelund, Birthe B. and Brooks, Andrew J. (2023). Tyrosine kinases compete for growth hormone receptor binding and regulate receptor mobility and degradation. Cell Reports, 42 (5) 112490, 112490. doi: 10.1016/j.celrep.2023.112490

Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG‐Syt1 ‐ SV2 plasma membrane nanocluster for synaptic vesicle entry

Joensuu, Merja, Syed, Parnayan, Saber, Saber H., Lanoue, Vanessa, Wallis, Tristan P., Rae, James, Blum, Ailisa, Gormal, Rachel S., Small, Christopher, Sanders, Shanley, Jiang, Anmin, Mahrhold, Stefan, Krez, Nadja, Cousin, Michael A., Cooper‐White, Ruby, Cooper‐White, Justin J., Collins, Brett M., Parton, Robert G., Balistreri, Giuseppe, Rummel, Andreas and Meunier, Frédéric A. (2023). Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG‐Syt1 ‐ SV2 plasma membrane nanocluster for synaptic vesicle entry. The EMBO Journal, 42 (13) e112095, e112095. doi: 10.15252/embj.2022112095

EndophilinA-dependent coupling between activity-induced calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation

Bademosi, Adekunle T., Decet, Marianna, Kuenen, Sabine, Calatayud, Carles, Swerts, Jef, Gallego, Sandra F., Schoovaerts, Nils, Karamanou, Spyridoula, Louros, Nikolaos, Martin, Ella, Sibarita, Jean-Baptiste, Vints, Katlijn, Gounko, Natalia V., Meunier, Frédéric A., Economou, Anastassios, Versées, Wim, Rousseau, Frederic, Schymkowitz, Joost, Soukup, Sandra-F. and Verstreken, Patrik (2023). EndophilinA-dependent coupling between activity-induced calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation. Neuron, 111 (9), 1402-1422.e13. doi: 10.1016/j.neuron.2023.02.001

Gut microbial DNA and immune checkpoint gene Vsig4/CRIg are key antagonistic players in healthy aging and age-associated development of hypertension and diabetes

Liu, Matthew A., Shahabi, Shandy, Jati, Suborno, Tang, Kechun, Gao, Hong, Jin, Zhongmou, Miller, Wyatt, Meunier, Frédéric A., Ying, Wei, Bogaart, Geert van den, Ghosh, Gourisankar and Mahata, Sushil K. (2022). Gut microbial DNA and immune checkpoint gene Vsig4/CRIg are key antagonistic players in healthy aging and age-associated development of hypertension and diabetes. Frontiers in Endocrinology, 13 1037465, 1-18. doi: 10.3389/fendo.2022.1037465

Fyn nanoclustering requires switching to an open conformation and is enhanced by FTLD-Tau biomolecular condensates

Martínez-Mármol, Ramón, Small, Christopher, Jiang, Anmin, Palliyaguru, Tishila, Wallis, Tristan P., Gormal, Rachel S., Sibarita, Jean-Baptiste, Götz, Jürgen and Meunier, Frédéric A. (2022). Fyn nanoclustering requires switching to an open conformation and is enhanced by FTLD-Tau biomolecular condensates. Molecular Psychiatry, 28 (2), 946-862. doi: 10.1038/s41380-022-01825-y

Ancestral SARS-CoV-2, but not Omicron, replicates less efficiently in primary pediatric nasal epithelial cells

Zhu, Yanshan, Chew, Keng Yih, Wu, Melanie, Karawita, Anjana C., McCallum, Georgina, Steele, Lauren E., Yamamoto, Ayaho, Labzin, Larisa I., Yarlagadda, Tejasri, Khromykh, Alexander A., Wang, Xiaohui, Sng, Julian D. J., Stocks, Claudia J., Xia, Yao, Kollmann, Tobias R., Martino, David, Joensuu, Merja, Meunier, Frédéric A., Balistreri, Giuseppe, Bielefeldt-Ohmann, Helle, Bowen, Asha C., Kicic, Anthony, Sly, Peter D., Spann, Kirsten M. and Short, Kirsty R. (2022). Ancestral SARS-CoV-2, but not Omicron, replicates less efficiently in primary pediatric nasal epithelial cells. PLoS Biology, 20 (8) e3001728, 1-19. doi: 10.1371/journal.pbio.3001728

Nanoscale organization of the pre-synapse: tracking the neurotransmitter release machinery

Gormal, Rachel S. and Meunier, Frédéric A. (2022). Nanoscale organization of the pre-synapse: tracking the neurotransmitter release machinery. Current Opinion in Neurobiology, 75 102576, 1-10. doi: 10.1016/j.conb.2022.102576

Spatial redistribution of neurosecretory vesicles upon stimulation accelerates their directed transport to the plasma membrane

Schenk, Elaine B., Meunier, Frederic A. and Oelz, Dietmar B. (2022). Spatial redistribution of neurosecretory vesicles upon stimulation accelerates their directed transport to the plasma membrane. PLoS One, 17 (3) e0264521, e0264521. doi: 10.1371/journal.pone.0264521

Non-β-blocker enantiomers of propranolol and atenolol inhibit vasculogenesis in infantile hemangioma

Seebauer, Caroline T., Graus, Matthew S., Huang, Lan, McCann, Alex J., Wylie-Sears, Jill, Fontaine, Frank R., Karnezis, Tara, Zurakowski, David, Staffa, Steven J., Meunier, Frédéric A., Mulliken, John B., Bischoff, Joyce and Francois, Mathias (2022). Non-β-blocker enantiomers of propranolol and atenolol inhibit vasculogenesis in infantile hemangioma. Journal of Clinical Investigation, 132 (3) e151109. doi: 10.1172/jci151109

A dominant-negative SOX18 mutant disrupts multiple regulatory layers essential to transcription factor activity

McCann, Alex J., Lou, Jieqiong, Moustaqil, Mehdi, Graus, Matthew S, Blum, Ailisa, Fontaine, Frank, Liu, Hui, Luu, Winnie, Rudolffi-Soto, Paulina, Koopman, Peter, Sierecki, Emma, Gambin, Yann, Meunier, Frédéric A., Liu, Zhe, Hinde, Elizabeth and Francois, Mathias (2021). A dominant-negative SOX18 mutant disrupts multiple regulatory layers essential to transcription factor activity. Nucleic Acids Research, 49 (19), 10931-10955. doi: 10.1093/nar/gkab820

The axonal radial contractility: structural basis underlying a new form of neural plasticity

Pan, Xiaorong, Zhou, Yimin, Hotulainen, Pirta, Meunier, Frédéric A. and Wang, Tong (2021). The axonal radial contractility: structural basis underlying a new form of neural plasticity. BioEssays, 43 (8) 2100033, 1-13. doi: 10.1002/bies.202100033

Saturated free fatty acids and association with memory formation

Wallis, Tristan P., Venkatesh, Bharat G., Narayana, Vinod K., Kvaskoff, David, Ho, Alan, Sullivan, Robert K., Windels, François, Sah, Pankaj and Meunier, Frédéric A. (2021). Saturated free fatty acids and association with memory formation. Nature Communications, 12 (1) 3443, 3443. doi: 10.1038/s41467-021-23840-3

Caveolin-1 and cavin1 act synergistically to generate a unique lipid environment in caveolae

Zhou, Yong, Ariotti, Nicholas, Rae, James, Liang, Hong, Tillu, Vikas, Tee, Shern, Bastiani, Michele, Bademosi, Adekunle T., Collins, Brett M., Meunier, Frederic A., Hancock, John F. and Parton, Robert G. (2021). Caveolin-1 and cavin1 act synergistically to generate a unique lipid environment in caveolae. Journal of Cell Biology, 220 (3) e202005138. doi: 10.1083/jcb.202005138

Modular transient nanoclustering of activated β2-adrenergic receptors revealed by single-molecule tracking of conformation-specific nanobodies

Gormal, Rachel S., Padmanabhan, Pranesh, Kasula, Ravikiran, Bademosi, Adekunle T., Coakley, Sean, Giacomotto, Jean, Blum, Ailisa, Joensuu, Merja, Wallis, Tristan P., Lo, Harriet P., Budnar, Srikanth, Rae, James, Ferguson, Charles, Bastiani, Michele, Thomas, Walter G., Pardon, Els, Steyaert, Jan, Yap, Alpha S., Goodhill, Geoffrey J., Hilliard, Massimo A., Parton, Robert G. and Meunier, Frédéric A. (2020). Modular transient nanoclustering of activated β2-adrenergic receptors revealed by single-molecule tracking of conformation-specific nanobodies. Proceedings of the National Academy of Sciences of the United States of America, 117 (48), 30476-30487. doi: 10.1073/pnas.2007443117

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

Cantuti-Castelvetri, Ludovico, Ojha, Ravi, Pedro, Liliana D., Djannatian, Minou, Franz, Jonas, Kuivanen, Suvi, van der Meer, Franziska, Kallio, Katri, Kaya, Tuğberk, Anastasina, Maria, Smura, Teemu, Levanov, Lev, Szirovicza, Leonora, Tobi, Allan, Kallio-Kokko, Hannimari, Österlund, Pamela, Joensuu, Merja, Meunier, Frédéric A., Butcher, Sarah J., Winkler, Martin Sebastian, Mollenhauer, Brit, Helenius, Ari, Gokce, Ozgun, Teesalu, Tambet, Hepojoki, Jussi, Vapalahti, Olli, Stadelmann, Christine, Balistreri, Giuseppe and Simons, Mikael (2020). Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity. Science, 370 (6518) abd2985, 856-860. doi: 10.1126/science.abd2985

An inverted CAV1 (caveolin 1) topology defines novel autophagy-dependent exosome secretion from prostate cancer cells

Ariotti, Nicholas, Wu, Yeping, Okano, Satomi, Gambin, Yann, Follett, Jordan, Rae, James, Ferguson, Charles, Teasdale, Rohan D., Alexandrov, Kirill, Meunier, Frederic A., Hill, Michelle M. and Parton, Robert G. (2020). An inverted CAV1 (caveolin 1) topology defines novel autophagy-dependent exosome secretion from prostate cancer cells. Autophagy, 17 (9), 1-17. doi: 10.1080/15548627.2020.1820787

An epilepsy-associated SV2A mutation disrupts Synaptotagmin-1 expression and activity-dependent trafficking

Harper, Callista B., Small, Christopher, Davenport, Elizabeth C., Low, Darryl W., Smillie, Karen J., Martínez-Mármol, Ramón, Meunier, Frédéric A. and Cousin, Michael A. (2020). An epilepsy-associated SV2A mutation disrupts Synaptotagmin-1 expression and activity-dependent trafficking. The Journal of Neuroscience, 40 (23), 4586-4595. doi: 10.1523/jneurosci.0210-20.2020

Radial contractility of actomyosin rings facilitates axonal trafficking and structural stability

Wang, Tong, Li, Wei, Martin, Sally, Papadopulos, Andreas, Joensuu, Merja, Liu, Chunxia, Jiang, Anmin, Shamsollahi, Golnoosh, Amor, Rumelo, Lanoue, Vanessa, Padmanabhan, Pranesh and Meunier, Frédéric A. (2020). Radial contractility of actomyosin rings facilitates axonal trafficking and structural stability. Journal of Cell Biology, 219 (5) e201902001, 1-S7. doi: 10.1083/jcb.201902001

Phospholipases in neuronal function: a role in learning and memory?

Joensuu, Merja, Wallis, Tristan P., Saber, Saber H. and Meunier, Frédéric A. (2019). Phospholipases in neuronal function: a role in learning and memory?. Journal of Neurochemistry, 153 (3) jnc.14918, e14918-333. doi: 10.1111/jnc.14918

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Brown, Peter, Tan, Aik-Choon, El-Esawi, Mohamed A., Liehr, Thomas, Blanck, Oliver, Gladue, Douglas P., Almeida, Gabriel M. F., Cernava, Tomislav, Sorzano, Carlos O., Yeung, Andy W. K., Engel, Michael S., Chandrasekaran, Arun Richard, Muth, Thilo, Staege, Martin S., Daulatabad, Swapna V., Widera, Darius, Zhang, Junpeng, Meule, Adrian, Honjo, Ken, Pourret, Olivier, Yin, Cong-Cong, Zhang, Zhongheng, Cascella, Marco, Flegel, Willy A., Goodyear, Carl S., van Raaij, Mark J., Bukowy-Bieryllo, Zuzanna, Campana, Luca G., Kurniawan, Nicholas A. ... RELISH Consortium (2019). Large expert-curated database for benchmarking document similarity detection in biomedical literature search. Database-The Journal of Biological Databases and Curation, 2019, 1-67. doi: 10.1093/database/baz085

p110δ PI 3-kinase inhibition perturbs APP and TNFα trafficking, reduces plaque burden, dampens neuroinflammation and prevents cognitive decline in an Alzheimer's disease mouse model

Martínez-Mármol, Ramón, Mohannak, Nika, Qian, Lei, Wang, Tong, Gormal, Rachel S, Ruitenberg, Marc J, Vanhaesebroeck, Bart, Coulson, Elizabeth J and Meunier, Frédéric A (2019). p110δ PI 3-kinase inhibition perturbs APP and TNFα trafficking, reduces plaque burden, dampens neuroinflammation and prevents cognitive decline in an Alzheimer's disease mouse model. Journal of Neuroscience, 39 (40), 7976-7991. doi: 10.1523/JNEUROSCI.0674-19.2019

STXBP1 encephalopathy: connecting neurodevelopmental disorders with α-synucleinopathies?

Lanoue, Vanessa, Chai, Ye Jin, Brouillet, Julie Z., Weckhuysen, Sarah, Palmer, Elizabeth E., Collins, Brett M. and Meunier, Frederic A. (2019). STXBP1 encephalopathy: connecting neurodevelopmental disorders with α-synucleinopathies?. Neurology, 93 (3), 114-123. doi: 10.1212/WNL.0000000000007786

Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines

Padmanabhan, Pranesh, Martínez-Mármol, Ramón, Xia, Di, Götz, Jürgen and Meunier, Frédéric A. (2019). Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines. eLife, 8 e45040. doi: 10.7554/elife.45040

Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2

Brennan, Faith H., Jogia, Trisha, Gillespie, Ellen R., Blomster, Linda V., Li, Xaria X., Nowlan, Bianca, Williams, Gail M., Jacobson, Esther, Osborne, Geoff W., Meunier, Frederic A., Taylor, Stephen M., Campbell, Kate E., MacDonald, Kelli P.A., Levesque, Jean-Pierre, Woodruff, Trent M. and Ruitenberg, Marc J. (2019). Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2. JCI Insight, 4 (9) e98254. doi: 10.1172/jci.insight.98254

Need for speed: Super-resolving the dynamic nanoclustering of syntaxin-1 at exocytic fusion sites

Padmanabhan, Pranesh, Bademosi, Adekunle T., Kasula, Ravikiran, Lauwers, Elsa, Verstreken, Patrik and Meunier, Frédéric A. (2019). Need for speed: Super-resolving the dynamic nanoclustering of syntaxin-1 at exocytic fusion sites. Neuropharmacology, 169 107554, 107554. doi: 10.1016/j.neuropharm.2019.02.036

VAMP2 Binding to Munc18-1 Domain 3a Controls the Nanoscale Reorganization of the Plasma Membrane and Vesicle Interface During Vesicular Priming

Kasula, Ravikiran, Blum, Ailisa, Salla-Martret, Merce, Chai, Ye Jin, Jiang, Anmin, Wallis, Tristan P., Gormal, Rachel S., Brouillet, Julie Z., Padmanabhan, Pranesh, Weeratunga, Saroja K., Livingstone, Emma K., Mollazade, Mahdie, Joensuu, Merja, Martínez-Mármol, Ramón, Collins, Brett M. and Meunier, Frederic (2019). VAMP2 Binding to Munc18-1 Domain 3a Controls the Nanoscale Reorganization of the Plasma Membrane and Vesicle Interface During Vesicular Priming. SSRN Electronic Journal. doi: 10.2139/ssrn.3362260

Actin remodeling in regulated exocytosis: toward a mesoscopic view

Li, Pin, Bademosi, Adekunle T., Luo, Jincai and Meunier, Frederic A. (2018). Actin remodeling in regulated exocytosis: toward a mesoscopic view. Trends in Cell Biology, 28 (9), 685-697. doi: 10.1016/j.tcb.2018.04.004

A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation

Chhabra, Y., Wong, H. Y., Nikolajsen, L. F., Steinocher, H., Papadopulos, A., Tunny, K. A., Meunier, F. A., Smith, A. G., Kragelund, B. B., Brooks, A. J. and Waters, M. J. (2018). A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation. Oncogene, 37 (4), 489-501. doi: 10.1038/onc.2017.352

In vivo single-molecule tracking at the Drosophila presynaptic motor nerve terminal

Bademosi, Adekunle T., Lauwers, Elsa, Amor, Rumelo, Verstreken, Patrik, van Swinderen, Bruno and Meunier, Frédéric A (2018). In vivo single-molecule tracking at the Drosophila presynaptic motor nerve terminal. Journal of Visualized Experiments, 2018 (131) e56952. doi: 10.3791/56952

Trapping of Syntaxin1a in Presynaptic Nanoclusters by a Clinically Relevant General Anesthetic

Bademosi, Adekunle T. , Steeves, James, Karunanithi, Shanker, Zalucki, Oressia H, Gormal, Rachel S, Liu, Shu, Lauwers, Elsa, Verstreken, Patrik, Anggono, Victor, Meunier, Frederic A and van Swinderen, Bruno (2018). Trapping of Syntaxin1a in Presynaptic Nanoclusters by a Clinically Relevant General Anesthetic. Cell reports, 22 (2), 427-440. doi: 10.1016/j.celrep.2017.12.054

Amyloid-β and tau complexity - towards improved biomarkers and targeted therapies

Polanco, Juan Carlos, Li, Chuanzhou, Bodea, Liviu-Gabriel, Martinez-Marmol, Ramon, Meunier, Frederic A and Götz, Jürgen (2017). Amyloid-β and tau complexity - towards improved biomarkers and targeted therapies. Nature reviews. Neurology, 14 (1), 22-40. doi: 10.1038/nrneurol.2017.162

Visualizing endocytic recycling and trafficking in live neurons by subdiffractional tracking of internalized molecules

Joensuu, Merja, Martinez-Marmol, Ramon, Padmanabhan, Pranesh, Glass, Nick R., Durisic, Nela, Pelekanos, Matthew, Mollazade, Mahdie, Balistreri, Giuseppe, Amor, Rumelo, Cooper-White, Justin J., Goodhill, Geoffrey J. and Meunier, Frederic A. (2017). Visualizing endocytic recycling and trafficking in live neurons by subdiffractional tracking of internalized molecules. Nature Protocols, 12 (12), 2590-2622. doi: 10.1038/nprot.2017.116

G-protein-coupled inwardly rectifying potassium (GIRK) channel activation by the p75 neurotrophin receptor is required for amyloid beta toxicity

May, Linda M., Anggono, Victor, Gooch, Helen M., Jang, Se E., Matusica, Dusan, Kerbler, Georg M., Meunier, Frederic A., Sah, Pankaj and Coulson, Elizabeth J. (2017). G-protein-coupled inwardly rectifying potassium (GIRK) channel activation by the p75 neurotrophin receptor is required for amyloid beta toxicity. Frontiers in Neuroscience, 11 (455) 455. doi: 10.3389/fnins.2017.00455

ENA/VASP proteins regulate exocytosis by mediating myosin VI-dependent recruitment of secretory granules to the cortical actin network

Tomatis, Vanesa M., Josh, Peter, Papadopulos, Andreas, Gormal, Rachel S., Lanoue, Vanessa, Martin, Sally and Meunier, Frédéric A. (2017). ENA/VASP proteins regulate exocytosis by mediating myosin VI-dependent recruitment of secretory granules to the cortical actin network. Molecular and Cellular Neuroscience, 84, 100-111. doi: 10.1016/j.mcn.2017.07.005

A role for tropomyosins in activity-dependent bulk endocytosis?

Gormal, R. S., Valmas, N., Fath, T. and Meunier, F. A. (2017). A role for tropomyosins in activity-dependent bulk endocytosis?. Molecular and Cellular Neuroscience, 84, 112-118. doi: 10.1016/j.mcn.2017.04.003

The SAC1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals

Vanhauwaert, Roeland, Kuenen, Sabine, Masius, Roy, Bademosi, Adekunle, Manetsberger, Julia, Schoovaerts, Nils, Bounti, Laura, Gontcharenko, Serguei, Swerts, Jef, Vilain, Sven, Picillo, Marina, Barone, Paolo, Munshi, Shashini T., de Vrij, Femke M. S., Kushner, Steven A., Gounko, Natalia V., Mandemakers, Wim, Bonifati, Vincenzo, Meunier, Frederic A., Soukup, Sandra‐Fausia and Verstreken, Patrik (2017). The SAC1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals. EMBO Journal, 36 (10), 1392-1411. doi: 10.15252/embj.201695773

Comparative analyses of glycerotoxin expression unveil a novel structural organization of the bloodworm venom system

Richter, Sandy, Helm, Conrad, Meunier, Frederic A., Hering, Lars, Campbell, Lahcen I., Drukewitz, Stephan H., Undheim, Eivind A. B., Jenner, Ronald A., Schiavo, Giampietro and Bleidorn, Christoph (2017). Comparative analyses of glycerotoxin expression unveil a novel structural organization of the bloodworm venom system. BMC Evolutionary Biology, 17 (1) 64, 64. doi: 10.1186/s12862-017-0904-4

Erratum: In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters

Bademosi, Adekunle T., Lauwers, Elsa, Padmanabhan, Pranesh, Odierna, Lorenzo, Chai, Ye Jin, Papadopulos, Andreas, Goodhill, Geoffrey J., Verstreken, Patrik, van Swinderen, Bruno and Meunier, Frédéric A (2017). Erratum: In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters. Nature Communications, 8 (1) 14492. doi: 10.1038/ncomms14492

In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters

Bademosi, Adekunle T., Lauwers, Elsa, Padmanabhan, Pranesh, Odierna, Lorenzo, Chai, Ye Jin, Papadopulos, Andreas, Goodhill, Geoffrey J., Verstreken, Patrik, Van Swinderen, Bruno and Meunier, Frederic A. (2016). In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters. Nature Communications, 7 (1) 13660, 13660. doi: 10.1038/ncomms13660

Subdiffractional tracking of internalized molecules reveals heterogeneous motion states of synaptic vesicles

Joensuu, Merja, Padmanabhan, Pranesh, Durisic, Nela, Bademosi, Adekunle T. D., Cooper-Williams, Elizabeth, Morrow, Isabel C., Harper, Callista B., Jung, WooRam, Parton, Robert G., Goodhill, Geoffrey J., Papadopulos, Andreas and Meunier, Frederic A. (2016). Subdiffractional tracking of internalized molecules reveals heterogeneous motion states of synaptic vesicles. Journal of Cell Biology, 215 (2), 277-292. doi: 10.1083/jcb.201604001

Flux of signalling endosomes undergoing axonal retrograde transport is encoded by presynaptic activity and TrkB

Wang, Tong, Martin, Sally, Nguyen, Tam H., Harper, Callista B., Gormal, Rachel S., Martinez-Marmol, Ramon, Karunanithi, Shanker, Coulson, Elizabeth J., Glass, Nick R., Cooper-White, Justin J., Van Swinderen, Bruno and Meunier, Frederic A. (2016). Flux of signalling endosomes undergoing axonal retrograde transport is encoded by presynaptic activity and TrkB. Nature Communications, 7 (1) 12976, 12976. doi: 10.1038/ncomms12976

The Munc18-1 domain 3a hinge-loop controls syntaxin-1A nanodomain assembly and engagement with the SNARE complex during secretory vesicle priming

Kasula, Ravikiran, Chai, Ye Jin, Bademosi, Adekunle T., Harper, Callista B., Gormal, Rachel S., Morrow, Isabel C., Hosy, Eric, Collins, Brett M., Choquet, Daniel, Papadopulos, Andreas and Meunier, Frederic A. (2016). The Munc18-1 domain 3a hinge-loop controls syntaxin-1A nanodomain assembly and engagement with the SNARE complex during secretory vesicle priming. The Journal of Cell Biology, 214 (7) 847, 847-858. doi: 10.1083/jcb.201508118

Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregation

Chai, Ye Jin, Sierecki, Emma, Tomatis, Vanesa M., Gormal, Rachel S., Giles, Nichole, Morrow, Isabel C., Xia, Di, Götz, Jürgen, Parton, Robert G., Collins, Brett M., Gambin, Yann and Meunier, Frédéric A. (2016). Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregation. The Journal of Cell Biology, 214 (6) 705, 705-718. doi: 10.1083/jcb.201512016

Caotivating new roles of F-actin cortex in exocytosis and bulk endocytosis in neurosecretory cells

Meunier, Frederic A. and Gutierrez, Luis M. (2016). Caotivating new roles of F-actin cortex in exocytosis and bulk endocytosis in neurosecretory cells. Trends in Neurosciences, 39 (9), 605-613. doi: 10.1016/j.tins.2016.07.003

The 18th International Symposia on Chromaffin Cell Biology

Meunier, Frederic A. and Keating, Damien J. (2016). The 18th International Symposia on Chromaffin Cell Biology. Journal of Neurochemistry, 137 (6), 847-848. doi: 10.1111/jnc.13631

Botulinum neurotoxin type-A enters a non-recycling pool of synaptic vesicles

Harper, Callista B., Papadopulos, Andreas, Martin, Sally, Matthews, Daniel R., Morgan, Garry P., Nguyen, Tam H., Wang, Tong, Nair, Deepak, Choquet, Daniel and Meunier, Frederic A. (2016). Botulinum neurotoxin type-A enters a non-recycling pool of synaptic vesicles. Scientific Reports, 6 (6) 19654, 19654.1-19654.13. doi: 10.1038/srep19654

Profiling of free fatty acids using stable isotope tagging uncovers a role for saturated fatty acids in neuroexocytosis

Narayana, Vinod K., Tomatis, Vanesa M., Wang, Tong, Kvaskoff, David and Meunier, Frederic A. (2015). Profiling of free fatty acids using stable isotope tagging uncovers a role for saturated fatty acids in neuroexocytosis. Chemistry and Biology, 22 (11), 1552-1561. doi: 10.1016/j.chembiol.2015.09.010

Small molecules demonstrate the role of dynamin as a bi-directional regulator of the exocytosis fusion pore and vesicle release

Jackson, J., Papadopulos, A., Meunier, F. A., McCluskey, A., Robinson, P. J. and Keating, D. J. (2015). Small molecules demonstrate the role of dynamin as a bi-directional regulator of the exocytosis fusion pore and vesicle release. Molecular Psychiatry, 20 (7), 810-819. doi: 10.1038/mp.2015.56

Control of autophagosome axonal retrograde flux by presynaptic activity unveiled using botulinum neurotoxin type A

Wang, Tong, Martin, Sally, Papadopulos, Andreas, Harper, Callista B., Mavlyutov, Timur A., Niranjan, Dhevahi, Glass, Nick R., Cooper-White, Justin J., Sibarita, Jean-Baptiste, Choquet, Daniel, Davletov, Bazbek and Meunier, Frederic A. (2015). Control of autophagosome axonal retrograde flux by presynaptic activity unveiled using botulinum neurotoxin type A. Journal of Neuroscience, 35 (15), 6179-6194. doi: 10.1523/JNEUROSCI.3757-14.2015

Activity-driven relaxation of the cortical actomyosin II network synchronizes Munc18-1-dependent neurosecretory vesicle docking

Papadopulos, Andreas, Gomez, Guillermo A., Martin, Sally, Jackson, Jade, Gormal, Rachel S., Keating, Damien J., Yap, Alpha S. and Meunier, Frederic A. (2015). Activity-driven relaxation of the cortical actomyosin II network synchronizes Munc18-1-dependent neurosecretory vesicle docking. Nature Communications, 6 (6297) 6297, 1-11. doi: 10.1038/ncomms7297

An acto-myosin II constricting ring initiates the fission of activity-dependent bulk endosomes in neurosecretory cells

Gormal, Rachel S, Nguyen, Tam H, Martin, Sally, Papadopulos, Andreas and Meunier, Frederic A (2015). An acto-myosin II constricting ring initiates the fission of activity-dependent bulk endosomes in neurosecretory cells. Journal of Neuroscience, 35 (4), 1380-1389. doi: 10.1523/JNEUROSCI.3228-14.2015

A HIV-1 Tat mutant protein disrupts HIV-1 Rev function by targeting the DEAD-box RNA helicase DDX1

Lin, Min-Hsuan, Sivakumaran, Haran, Jones, Alun, Li, Dongsheng, Harper, Callista, Wei, Ting, Jin, Hongping, Rustanti, Lina, Meunier, Frederic A., Spann, Kirsten and Harrich, David (2014). A HIV-1 Tat mutant protein disrupts HIV-1 Rev function by targeting the DEAD-box RNA helicase DDX1. Retrovirology, 11 (1) 9, 121.1-121.16. doi: 10.1186/s12977-014-0121-9

Increased polyubiquitination and proteasomal degradation of a Munc18-1 disease-linked mutant causes temperature-sensitive defect in exocytosis

Martin, Sally, Papadopulos, Andreas, Tomatis, Vanesa M., Sierecki, Emma, Malintan, Nancy T., Gormal, Rachel S., Giles, Nichole, Johnston, Wayne A., Alexandrov, Kirill, Gambin, Yann, Collins, Brett M. and Meunier, Frederic A. (2014). Increased polyubiquitination and proteasomal degradation of a Munc18-1 disease-linked mutant causes temperature-sensitive defect in exocytosis. Cell Reports, 9 (1), 206-218. doi: 10.1016/j.celrep.2014.08.059

Decatenation checkpoint defective melanomas are dependent on PI3K for survival

Brooks, Kelly, Ranall, Max, Spoerri, Loredana, Stevenson, Alex, Gunasingh, Gency, Pavey, Sandra, Meunier, Fred, Gonda, Thomas J. and Gabrielli, Brian (2014). Decatenation checkpoint defective melanomas are dependent on PI3K for survival. Pigment Cell and Melanoma Research, 27 (5), 813-821. doi: 10.1111/pcmr.12268

A role for SNAREs in neuronal survival?

Harper, Callista B., Bademosi, Adekunle T., Coulson, Elizabeth J. and Meunier, Frederic A. (2014). A role for SNAREs in neuronal survival?. Journal of Neurochemistry, 129 (5), 753-755. doi: 10.1111/jnc.12699

Bulk endocytosis at neuronal synapses

Nguyen, Tam H., Qiu, XuFeng, Sun, Jian and Meunier, Frederic A. (2014). Bulk endocytosis at neuronal synapses. Science China Life Sciences, 57 (4), 378-383. doi: 10.1007/s11427-014-4636-z

PI3K delta inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model

Low, Pei Ching, Manzanero, Silvia, Mohannak, Nika, Narayana, Vinod K., Nguyen, Tam H., Kvaskoff, David, Brennan, Faith H., Ruitenberg, Marc J., Gelderblom, Mathias, Magnus, Tim, Kim, Hyun Ah, Broughton, Brad R. S., Sobey, Christopher G., Vanhaesebroeck, Bart, Stow, Jennifer L., Arumugam, Thiruma V. and Meunier, Frédéric A. (2014). PI3K delta inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model. Nature Communications, 5 (3450) 3450, 1-12. doi: 10.1038/ncomms4450

Mapping Organelle Motion Reveals a Vesicular Conveyor Belt Spatially Replenishing Secretory Vesicles in Stimulated Chromaffin Cells

Maucort, Guillaume, Kasula, Ravikiran, Papadopulos, Andreas, Nieminen, Timo A., Rubinsztein-Dunlop, Halina and Meunier, Frederic A. (2014). Mapping Organelle Motion Reveals a Vesicular Conveyor Belt Spatially Replenishing Secretory Vesicles in Stimulated Chromaffin Cells. PLoS One, 9 (1) e87242, e87242. doi: 10.1371/journal.pone.0087242

Building a better dynasore: the Dyngo compounds potently inhibit dynamin and endocytosis

McCluskey, Adam, Daniel, James A., Hadzic, Gordana, Chau, Ngoc, Clayton, Emma L., Mariana, Anna, Whiting, Ainslie, Gorgani, Nick N., Lloyd, Jonathan, Quan, Annie, Moshkanbaryans, Lia, Krishnan, Sai, Perera, Swetha, Chircop, Megan, von Kleist, Lisa, McGeachie, Andrew B., Howes, Mark T., Parton, Robert G., Campbell, Michael, Sakoff, Jennette A., Wang, Xuefeng, Sun, Jian-Yuan, Robertson, Mark J., Deane, Fiona M., Nguyen, Tam H., Meunier, Frederic A., Cousin, Michael A. and Robinson, Phillip J. (2013). Building a better dynasore: the Dyngo compounds potently inhibit dynamin and endocytosis. Traffic, 14 (12), 1272-1289. doi: 10.1111/tra.12119

The cortical acto-myosin network: from diffusion barrier to functional gateway in the transport of neurosecretory vesicles to the plasma membrane

Papadopulos, Andreas, Tomatis, Vanesa, Kasula, Ravikiran and Meunier, Frederic A. (2013). The cortical acto-myosin network: from diffusion barrier to functional gateway in the transport of neurosecretory vesicles to the plasma membrane. Frontiers in Endocrinology, 4 (153), 153.1-153.11. doi: 10.3389/fendo.2013.00153

Synthetic self-assembling clostridial chimera for modulation of sensory functions

Ferrari, Enrico, Gu, Chunjing, Niranjan, Dhevahi, Restani, Laura, Rasetti-Escargueil, Christine, Obara, Ilona, Geranton, Sandrine M., Arsenault, Jason, Goetze, Tom A., Harper, Callista B., Nguyen, Tam H., Maywood, Elizabeth, O'Brien, John, Schiavo, Giampietro, Wheeler, Daniel W., Meunier, Frederic A., Hastings, Michael, Edwardson, J. Michael, Sesardic, Dorothea, Caleo, Matteo, Hunt, Stephen P. and Davletov, Bazbek (2013). Synthetic self-assembling clostridial chimera for modulation of sensory functions. Bioconjugate Chemistry, 24 (10), 1750-1759. doi: 10.1021/bc4003103

The Munc18-1 domain 3a loop is essential for neuroexocytosis but not for syntaxin-1A transport to the plasma membrane

Martin, Sally, Tomatis, Vanesa M., Papadopulos, Andreas, Christie, Michelle P., Malintan, Nancy T., Gormal, Rachel S., Sugita, Shuzo, Martin, Jennifer L., Collins, Brett M. and Meunier, Frederic A. (2013). The Munc18-1 domain 3a loop is essential for neuroexocytosis but not for syntaxin-1A transport to the plasma membrane. Journal of Cell Science, 126 (11), 2353-2360. doi: 10.1242/jcs.126813

Inhibition of PIKfyve by YM-201636 Dysregulates Autophagy and Leads to Apoptosis-Independent Neuronal Cell Death

Martin, Sally, Harper, Callista B., May, Linda M., Coulson, Elizabeth J., Meunier, Frederic A. and Osborne, Shona L. (2013). Inhibition of PIKfyve by YM-201636 Dysregulates Autophagy and Leads to Apoptosis-Independent Neuronal Cell Death. PLoS One, 8 (3) e60152, e60152.1-e60152.14. doi: 10.1371/journal.pone.0060152

Myosin VI small insert isoform maintains exocytosis by tethering secretory granules to the cortical actin

Tomatis, Vanesa M., Papadopulos, Andreas, Malintan, Nancy T., Martin, Sally, Wallis, Tristan, Gormal, Rachel S., Kendrick-Jones, John, Buss, Folma and Meunier, Frederic A. (2013). Myosin VI small insert isoform maintains exocytosis by tethering secretory granules to the cortical actin. Journal of Cell Biology, 200 (3), 301-320. doi: 10.1083/jcb.201204092

Targeting membrane trafficking in infection prophylaxis: dynamin inhibitors

Harper, Callista B., Popoff, Michel R., McCluskey, Adam, Robinson, Phillip J. and Meunier, Frederic A. (2013). Targeting membrane trafficking in infection prophylaxis: dynamin inhibitors. Trends in Cell Biology, 23 (2), 90-101. doi: 10.1016/j.tcb.2012.10.007

Secretagogue stimulation of neurosecretory cells elicits filopodial extensions uncovering new functional release sites

Papadopulos, Andreas, Martin, Sally, Tomatis, Vanesa M., Gormal, Rachel S. and Meunier, Frederic A. (2013). Secretagogue stimulation of neurosecretory cells elicits filopodial extensions uncovering new functional release sites. Journal of Neuroscience, 33 (49), 19143-19153. doi: 10.1523/JNEUROSCI.2634-13.2013

Actin- and dynamin-dependent maturation of bulk endocytosis restores neurotransmission following synaptic depletion

Nguyen, Tam H., Maucort, Guillaume, Sullivan, Robert K. P., Schenning, Mitja, Lavidis, Nickolas A., McCluskey, Adam, Robinson, Phillip J. and Meunier, Frederic A. (2012). Actin- and dynamin-dependent maturation of bulk endocytosis restores neurotransmission following synaptic depletion. PLoS One, 7 (5 Article No.e36913) e36913, e36913. doi: 10.1371/journal.pone.0036913

Munc18-1 domain-1 controls vesicle docking and secretion by interacting with syntaxin-1 and chaperoning it to the plasma membrane

Han, Gayoung A., Malintan, Nancy T., Saw, Ner Mu Nar, Li, Lijun, Han, Liping, Meunier, Frederic A., Collins, Brett M. and Sugita, Shuzo (2011). Munc18-1 domain-1 controls vesicle docking and secretion by interacting with syntaxin-1 and chaperoning it to the plasma membrane. Molecular Biology of The Cell, 22 (21), 4134-4149. doi: 10.1091/mbc.E11-02-0135

Dynamin inhibition blocks botulinum neurotoxin type A endocytosis in neurons and delays botulism

Harper, Callista B., Martin, Sally, Nguyen, Tam H., Daniels, Shari J., Lavidis, Nickolas A., Popoff, Michel R., Hadzic, Gordana, Mariana, Anna, Chau, Ngoc, McCluskey, Adam, Robinson, Phillip J. and Meunier, Frederic A. (2011). Dynamin inhibition blocks botulinum neurotoxin type A endocytosis in neurons and delays botulism. Journal of Biological Chemistry, 286 (41), 35966-35976. doi: 10.1074/jbc.M111.283879

Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells

Wen, Peter J., Osborne, Shona L., Zanin, Mark, Low, Pei Ching, Wang, Hai-Tao A., Schoenwaelder, Simone M., Jackson, Shaun P., Wedlich-Soldner, Roland, Vanhaesebroeck, Bart, Keating, Damien J. and Meunier, Frederic A. (2011). Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells. Nature Communications, 2 (1) 757, 491.1-491.11. doi: 10.1038/ncomms1500

Dynamic control of neuroexocytosis by phosphoinositides in health and disease

Wen, Peter, Osborne, Shona L. and Meunier, Frederic A. (2011). Dynamic control of neuroexocytosis by phosphoinositides in health and disease. Progress in Lipid Research, 50 (1), 52-61. doi: 10.1016/j.plipres.2010.08.001

Ciguatoxin-induced catecholamine secretion in bovine chromaffin cells: Mechanism of action and reversible inhibition by brevenal

Nguyen-Huu, Truong D., Mattei, César, Wen, Peter J., Bourdelais, Andrea J., Lewis, Richard J., Benoit, Evelyne, Baden, Daniel G., Molgó, Jordi and Meunier, Frédéric A. (2010). Ciguatoxin-induced catecholamine secretion in bovine chromaffin cells: Mechanism of action and reversible inhibition by brevenal. Toxicon, 56 (5), 792-796. doi: 10.1016/j.toxicon.2009.08.002

Munc18-1 as a key regulator of neurosecretion

Han, GA, Malintan, NT, Collins, BM, Meunier, FA and Sugita, S (2010). Munc18-1 as a key regulator of neurosecretion. Journal of Neurochemistry, 115 (1), 1-10. doi: 10.1111/j.1471-4159.2010.06900.x

Phosphoinositide 3-kinase δ regulates membrane fission of Golgi carriers for selective cytokine secretion

Low, Pei Ching, Misaki, Ryo, Schroder, Kate, Stanley, Amanda C., Sweet, Matthew J., Teasdale, Rohan D., Vanhaesebroeck, Bart, Meunier, Frédéric A., Taguchi, Tomohiko and Stow, Jennifer L. (2010). Phosphoinositide 3-kinase δ regulates membrane fission of Golgi carriers for selective cytokine secretion. Journal of Cell Biology, 190 (6), 1053-1065. doi: 10.1083/jcb.201001028

Regioselective Approach to Phosphatidylinositol 3,5-Bisphosphates: Syntheses of the Native Phospholipid and Biotinylated Short-Chain Derivative

Anderson, Regan J., Osborne, Shona L., Meunier, Frederic A and Painter, Gavin F. (2010). Regioselective Approach to Phosphatidylinositol 3,5-Bisphosphates: Syntheses of the Native Phospholipid and Biotinylated Short-Chain Derivative. Journal of Organic Chemistry, 75 (11), 3541-3551. doi: 10.1021/jo100393c

Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella

Kerr, Markus C., Wang, Jack T. H., Castro, Natalie A., Hamilton, Nicholas A., Town, Liam, Brown, Darren L., Meunier, Frederic A., Brown, Nat F., Stow, Jennifer L. and Teasdale, Rohan D. (2010). Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella. EMBO Journal, 29 (8), 1331-1347. doi: 10.1038/emboj.2010.28

Sustained synaptic-vesicle recycling by bulk endocytosis contributes to the maintenance of high-rate neurotransmitter release stimulated by glycerotoxin

Meunier, Frederic A., Nguyen, Tam H., Colasante, Cesare, Luo, Fujun, Sullivan, Robert K. P., Lavidis, Nicholas A., Molgo, Jordi, Meriney, Stephen D. and Schiavo, Giampietro (2010). Sustained synaptic-vesicle recycling by bulk endocytosis contributes to the maintenance of high-rate neurotransmitter release stimulated by glycerotoxin. Journal of Cell Science, 123 (7), 1131-1140. doi: 10.1242/jcs.049296

Rescue of Munc18-1 and -2 double knockdown reveals the essential functions of interaction between Munc18 and closed syntaxin in PC12 cells

Han, Liping, Jiang, Tiandan, Han, Gayoung A., Malintan, Nancy T., Xie, Li., Wang, Li., Tse, Frederick W., Gaisano, Herbert Y., Collins, Brett M., Meunier, Frederic A. and Sugita, Shuzo (2009). Rescue of Munc18-1 and -2 double knockdown reveals the essential functions of interaction between Munc18 and closed syntaxin in PC12 cells. Molecular Biology of the Cell, 20 (23), 4962-4975. doi: 10.1091/mbc.E09-08-0712

Abrogating Munc18-1 SNARE complex interaction has limited impact on exocytosis in PC12 cells

Malintan, Nancy, Nguyen, Tam H, Han, Liping, Latham, Catherine F., Osborne, Shona L., Wen, Peter, Lim, Siew, Joo, Tiffany, Sugita, Shuzo, Collins, Brett M. and Meunier, Frederic A. (2009). Abrogating Munc18-1 SNARE complex interaction has limited impact on exocytosis in PC12 cells. The Journal of Biological Chemistry, 284 (32), 21637-21646. doi: 10.1074/jbc.M109.013508

Ca2+-regulated pool of phosphatidylinositol-3-phosphate produced by phosphatidylinositol 3-kinase C2α on neurosecretory vesicles

Wen, Peter, Osborne, Shona L., Morrow, Isabel C., Parton, Robert G., Domin, Jan and Meunier, Frederic A. (2008). Ca2+-regulated pool of phosphatidylinositol-3-phosphate produced by phosphatidylinositol 3-kinase C2α on neurosecretory vesicles. Molecular Biology of the Cell, 19 (12), 5593-5603. doi: 10.1091/mbc.E08-06-0595

Brevenal Inhibits Pacific Ciguatoxin-1B-Induced Neurosecretion from Bovine Chromaffin Cells

Mattei, C, Wen, PJ, Nguyen-Huu, TD, Alvarez, M, Benoit, E, Bourdelais, AJ, Lewis, RJ, Baden, DG, Molgo, J and Meunier, FA (2008). Brevenal Inhibits Pacific Ciguatoxin-1B-Induced Neurosecretion from Bovine Chromaffin Cells. PLoS One, 3 (10) e3448, 1-16. doi: 10.1371/journal.pone.0003448

PIKfyve Negatively Regulates Exocytosis in Neurosecretory Cells

Osborne, Shona L., Wen, Peter J., Boucheron, Christine, Nguyen, Hao N., Hayakawa, Masahiko, Kaizawa, Hiroyuki, Parker, Peter J., Vitale, Nicolas and Meunier, Frederic A. (2008). PIKfyve Negatively Regulates Exocytosis in Neurosecretory Cells. Journal of Biological Chemistry, 283 (5), 2804-2813. doi: 10.1074/jbc.M704856200

p75 neurotrophin receptor mediates neuronal cell death by activating GIRK channels through phosphatidylinositol 4,5-bisphosphate

Coulson, E. J., May, L. M., Osborne, S. L., Reid, K., Underwood, C. K., Meunier, F. A., Bartlett, P. F. and Sah, P. (2008). p75 neurotrophin receptor mediates neuronal cell death by activating GIRK channels through phosphatidylinositol 4,5-bisphosphate. Journal of Neuroscience, 28 (1), 315-324. doi: 10.1523/JNEUROSCI.2699-07.2008

Arachidonic acid potentiates exocytosis and allows neuronal SNARE complex to interact with Munc18a

Latham, C. F., Osborne, S. L., Cryle, M. J. and Meunier, F. A. (2007). Arachidonic acid potentiates exocytosis and allows neuronal SNARE complex to interact with Munc18a. Journal of Neurochemistry, 100 (6), 1543-1554. doi: 10.1111/j.1471-4159.2006.04286.x

Identification of secretory granule phosphatidylinositol 4,5-bisphosphateinteracting proteins using an affinity pulldown strategy

Osborne, SL, Wallis, TP, Jimenez, JL, Gorman, JJ and Meunier, FA (2007). Identification of secretory granule phosphatidylinositol 4,5-bisphosphateinteracting proteins using an affinity pulldown strategy. Molecular and Cellular Proteomics, 6 (7), 1158-1169. doi: 10.1074/mcp.M600430-MCP200

Munc 18a: Munc-y business in mediating exocytosis

Latham, CF and Meunier, FA (2007). Munc 18a: Munc-y business in mediating exocytosis. International Journal of Biochemistry & Cell Biology, 39 (9), 1576-1581. doi: 10.1016/j.biocel.2006.11.015

The janus faces of botulinum neurotoxin: Sensational medicine and deadly biological weapon

Osborne, SL, Latham, CF, Wen, PJ, Cavaignac, S, Fanning, J, Foran, PG and Meunier, FA (2007). The janus faces of botulinum neurotoxin: Sensational medicine and deadly biological weapon. Journal of Neuroscience Research, 85 (6), 1149-1158. doi: 10.1002/jnr.21171

Glycerotoxin stimulates neurotransmitter release from N-type Ca2+ channel expressing neurons

Schenning, Mitja, Proctor, Dustin T., Ragnarsson, Lotten, Barbier, Julien, Lavidis, Nickolas A., Molgo, Jordi J., Zamponi, Gerald W., Schiavo, Giampietro and Meunier, Frederic A. (2006). Glycerotoxin stimulates neurotransmitter release from N-type Ca2+ channel expressing neurons. Journal of Neurochemistry, 98 (3), 894-904. doi: 10.1111/j.1471-4159.2006.03938.x

High throughput analysis of endogenous glutamate release using a fluorescence plate reader

Sim, Alistair T.R., Herd, Lynn, Proctor, Dustin T., Baldwin, Monique L., Meunier, Frederic A. and Rostas, John A.P (2006). High throughput analysis of endogenous glutamate release using a fluorescence plate reader. Journal of Neuroscience Methods, 153 (1), 43-47. doi: 10.1016/j.jneumeth.2005.10.004

Phosphoinositide regulation of neuroexocytosis: adding to the complexity

Osborne, Shona L., Wen, Peter J. and Meunier, Frederic A. (2006). Phosphoinositide regulation of neuroexocytosis: adding to the complexity. Journal of Neurochemistry, 98 (2), 336-342. doi: 10.1111/j.1471-4159.2006.03892.x

Phosphatidylinositol 3-kinase C2 alpha is essential for ATP-dependent priming of neurosecretory granule exocytosis

Meunier, Frederic A., Osborne, Shona L., Hammond, Gerald R.V., Cooke, Frank T., Parker, Peter J., Domin, Jan and Schiavo, Giampietro (2005). Phosphatidylinositol 3-kinase C2 alpha is essential for ATP-dependent priming of neurosecretory granule exocytosis. Molecular Biology of The Cell, 16 (10), 4841-4851. doi: 10.1091/mbc.E05-02-0171

Engineering stable peptide toxins by means of backbone cyclization: Stabilization of the alpha-conotoxin MII

Clark, R. J., Fischer, H., Dempster, L., Daly, N. L., Rosengren, K. J., Nevin, S. T., Meunier, F. A., Adams, D. J. and Craik, D. J. (2005). Engineering stable peptide toxins by means of backbone cyclization: Stabilization of the alpha-conotoxin MII. Proceedings of The National Academy of Sciences of The United States of America, 102 (39), 13767-13772. doi: 10.1073/pnas.0504613102

Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphate

Rickman, Colin, Archer, Deborah A., Meunier, Frederic A., Craxton, Molly, Fukuda, Mitsunori, Burgoyne, Robert D. and Davletov, Bazbek (2004). Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphate. Journal of Biological Chemistry, 279 (13), 12574-12579. doi: 10.1074/jbc.M310710200

High affinity interaction of syntaxin and SNAP-25 on the plasma membrane is abolished by botulinum toxin E

Rickman, Colin, Meunier, Frederic A., Binz, Thomas and Davletov, Bazbek (2004). High affinity interaction of syntaxin and SNAP-25 on the plasma membrane is abolished by botulinum toxin E. Journal of Biological Chemistry, 279 (1), 644-651. doi: 10.1074/jbc.M310879200

Dynamics of motor nerve terminal remodeling unveiled using SNARE-cleaving botulinum toxins: the extent and duration are dictated by the sites of SNAP-25 truncation

Meunier, Frederic, Lisk, Godfrey, Sesardic, Dorothea and Dolly, J. Oliver (2003). Dynamics of motor nerve terminal remodeling unveiled using SNARE-cleaving botulinum toxins: the extent and duration are dictated by the sites of SNAP-25 truncation. Molecular and Cellular Neuroscience, 22 (4), 454-466. doi: 10.1016/S1044-7431(02)00016-7

Functional recycling of C2 domains throughout evolution: A comparative study of synaptotagmin, protein kinase C and phospholipase C by sequence, structural and modelling approaches

Jimenez, J. L., Smith, G. R., Contreras-Moreira, B., Sgouros, J. G., Meunier, F. A., Bates, P. A. and Schiavo, G. (2003). Functional recycling of C2 domains throughout evolution: A comparative study of synaptotagmin, protein kinase C and phospholipase C by sequence, structural and modelling approaches. Journal of Molecular Biology, 333 (3), 621-639. doi: 10.1016/j.jmb.2003.08.052

Getting muscles moving again after botulinum toxin: novel therapeutic challenges

Foran, PG, Davletov, B and Meunier, FA (2003). Getting muscles moving again after botulinum toxin: novel therapeutic challenges. Trends In Molecular Medicine, 9 (7), 291-299. doi: 10.1016/S1471-4914(03)00113-8

Botulinum neurotoxins: from paralysis to recovery of functional neuromuscular transmission

Meunier, FA, Schiavo, G and Molgo, J (2002). Botulinum neurotoxins: from paralysis to recovery of functional neuromuscular transmission. Journal of Physiology-paris, 96 (1-2), 105-113. doi: 10.1016/S0928-4257(01)00086-9

Clostridial neurotoxins

Verastegui, C., Lalli, G., Bohnert, S., Meunier, F. A. and Schiavo, G. (2002). Clostridial neurotoxins. Journal of Toxicology-toxin Reviews, 21 (3), 203-227. doi: 10.1081/TXR-120014404

Glycerotoxin from Glycera convoluta stimulates neurosecretion by up-regulating N-type Ca2+ channel activity

Meunier, Frédéric A., Feng, Zhong-Ping, Molgó, Jordi, Zamponi, Gerald W. and Schiavo, Giampietro (2002). Glycerotoxin from Glycera convoluta stimulates neurosecretion by up-regulating N-type Ca2+ channel activity. The EMBO Journal, 21 (24), 6733-6743. doi: 10.1093/emboj/cdf677

Ionic mechanisms involved in the nodal swelling of myelinated axons caused by marine toxins

Benoit, Evelyne, Mattei, Cesar, Ouanounou, Gilles, Meunier, Frederic A., Suput, Dusan, Le Gall, Frederic, Marquais, Michel, Dechraoui, Marie Y. and Molgo, Jordi (2002). Ionic mechanisms involved in the nodal swelling of myelinated axons caused by marine toxins. Cellular & Molecular Biology Letters, 7 (2), 317-321.

Phosphoinositides as key regulators of synaptic function

Osborne, Shona L., Meunier, Frédéric A. and Schiavo, Giampietro (2001). Phosphoinositides as key regulators of synaptic function. Neuron, 32 (1), 9-12. doi: 10.1016/S0896-6273(01)00455-X

Latrophilin, neurexin, and their signaling-deficient mutants facilitate α-latrotoxin insertion into membranes but are not involved in pore formation

Volynski, KE, Meunier, FA, Lelianova, VG, Dudina, EE, Volkova, TM, Rahman, MA, Manser, C, Grishin, EV, Dolly, JO, Ashley, RH and Ushkaryov, YA (2000). Latrophilin, neurexin, and their signaling-deficient mutants facilitate α-latrotoxin insertion into membranes but are not involved in pore formation. Journal of Biological Chemistry, 275 (52), 41175-41183. doi: 10.1074/jbc.M005857200

Ca2+ and Na+ contribute to the swelling of differentiated neuroblastoma cells induced by equinatoxin-II

Meunier, FA, Frangez, R, Benoit, E, Ouanounou, G, Rouzaire-Dubois, B, Suput, D and Molgo, J (2000). Ca2+ and Na+ contribute to the swelling of differentiated neuroblastoma cells induced by equinatoxin-II. Toxicon, 38 (11), 1547-1560. doi: 10.1016/S0041-0101(00)00088-X

Equinatoxin II increases intracellular Ca2+ in NG 108–15 cells

Frangež, Robert, Meunier, Frederick, Molgo, Jordi and Suput, Dusan (2000). Equinatoxin II increases intracellular Ca2+ in NG 108–15 cells. Pflugers Archiv European Journal of Physiology, 439 (7), R100-R101. doi: 10.1007/BF03376535

Trachynilysin mediates SNARE-dependent release of catecholamines from chromaffin cells via external and stored Ca2+

Meunier, FA, Mattei, C, Chameau, P, Lawrence, G, Colasante, C, Kreger, AS, Dolly, JO and Molgo, J (2000). Trachynilysin mediates SNARE-dependent release of catecholamines from chromaffin cells via external and stored Ca2+. Journal of Cell Science, 113 (7), 1119-1125.

Effects of trachynilysin, a protein isolated from stonefish (Synanceia trachynis) venom, on frog atrial heart muscle

Sauviat, MP, Meunier, FA, Kreger, A and Molgo, J (2000). Effects of trachynilysin, a protein isolated from stonefish (Synanceia trachynis) venom, on frog atrial heart muscle. Toxicon, 38 (7), 945-959. doi: 10.1016/S0041-0101(99)00207-X

Trachynilysin, a protein neurotoxin isolated from stonefish (Synanceia trachynis) venom, increases spontaneous quantal acetylcholine release from Torpedo marmorata neuromuscular junctions

Ouanounou, G, Mattei, C, Meunier, FA, Kreger, AS and Molgo, J (2000). Trachynilysin, a protein neurotoxin isolated from stonefish (Synanceia trachynis) venom, increases spontaneous quantal acetylcholine release from Torpedo marmorata neuromuscular junctions. Cybium, 24 (3), 149-156.

Recreation of neuronal Kv1 channel oligomers by expression in mammalian cells using semliki forest virus

Shamotienko, O, Akhtar, S, Sidera, C, Meunier, FA, Ink, B, Weir, M and Dolly, JO (1999). Recreation of neuronal Kv1 channel oligomers by expression in mammalian cells using semliki forest virus. Biochemistry, 38 (51), 16766-16776. doi: 10.1021/bi991039n

Neurotoxins targetting receptor site 5 of voltage-dependent sodium channels increase the nodal volume of myelinated axons

Mattei, C, Dechraoui, MY, Molgo, J, Meunier, FA, Legrand, AM and Benoit, E (1999). Neurotoxins targetting receptor site 5 of voltage-dependent sodium channels increase the nodal volume of myelinated axons. Journal of Neuroscience Research, 55 (6), 666-673. doi: 10.1002/(SICI)1097-4547(19990315)55:6<666::AID-JNR2>3.0.CO;2-H

Norepinephrine exocytosis stimulated by alpha-latrotoxin requires both external and stored Ca2+ and is mediated by latrophilin, G proteins and phospholipase C

Rahman, MA, Ashton, AC, Meunier, FA, Davletov, BA, Dolly, JO and Ushkaryov, YA (1999). Norepinephrine exocytosis stimulated by alpha-latrotoxin requires both external and stored Ca2+ and is mediated by latrophilin, G proteins and phospholipase C. Philosophical Transactions of the Royal Society of London Series B-Biological Sciences, 354 (1381), 379-386. doi: 10.1098/rstb.1999.0390

Vesicle exocytosis stimulated by α-latrotoxin is mediated by latrophilin and requires both external and stored Ca2+

Davletov, BA, Meunier, FA, Ashton, AC, Matsushita, H, Hirst, WD, Lelianova, VG, Wilkin, GP, Dolly, JO and Ushkaryov, YA (1998). Vesicle exocytosis stimulated by α-latrotoxin is mediated by latrophilin and requires both external and stored Ca2+. EMBO Journal, 17 (14), 3909-3920. doi: 10.1093/emboj/17.14.3909

The peripheral nerve and the neuromuscular junction are affected in the tenascin-C-deficient mouse

Cifuentes-Diaz, C, Velasco, E, Meunier, FA, Goudou, D, Belkadi, L, Faille, L, Murawsky, M, Angaut-Petit, D, Molgo, J, Schachner, M, Saga, Y, Aizawa, S and Rieger, F (1998). The peripheral nerve and the neuromuscular junction are affected in the tenascin-C-deficient mouse. Cellular and Molecular Biology, 44 (2), 357-379.

Marine Toxins Affecting Quantal Acetylcholine Release and Transmission at the Vertebrate Neuromuscular Junction

Molgó, Jordi, Meunier, Frédéric A., Colasante, Cesare and Poulain, Bernard (1997). Marine Toxins Affecting Quantal Acetylcholine Release and Transmission at the Vertebrate Neuromuscular Junction. Advances in Organ Biology, 2 (C), 249-284. doi: 10.1016/S1569-2590(08)60189-5

Sodium-dependent increase in quantal secretion induced by brevetoxin-3 in Ca2+-free medium is associated with depletion of synaptic vesicles and swelling of motor nerve terminals in situ

Meunier, FA, Colasante, C and Molgo, J (1997). Sodium-dependent increase in quantal secretion induced by brevetoxin-3 in Ca2+-free medium is associated with depletion of synaptic vesicles and swelling of motor nerve terminals in situ. Neuroscience, 78 (3), 883-893. doi: 10.1016/S0306-4522(96)00568-4

Nitric oxide and peroxynitrite affect differently acetylcholine release, choline acetyltransferase activity, synthesis, and compartmentation of newly formed acetylcholine in Torpedo marmorata synaptosomes

Gaudry-Talarmain, YM, Moulian, N, Meunier, FA, Blanchard, B, Angaut-Petit, D, Faille, L and Ducrocq, C (1997). Nitric oxide and peroxynitrite affect differently acetylcholine release, choline acetyltransferase activity, synthesis, and compartmentation of newly formed acetylcholine in Torpedo marmorata synaptosomes. Nitric Oxide - Biology and Chemistry, 1 (4), 330-345. doi: 10.1006/niox.1997.0141

Selective depolarization of the muscle membrane in frog nerve-muscle preparations by a chromatographically purified extract of the dinoflagellate Ostreopsis lenticularis

Meunier, FA, Mercado, JA, Molgo, J, Tosteson, TR and deMotta, GE (1997). Selective depolarization of the muscle membrane in frog nerve-muscle preparations by a chromatographically purified extract of the dinoflagellate Ostreopsis lenticularis. British Journal of Pharmacology, 121 (6), 1224-1230. doi: 10.1038/sj.bjp.0701256

Enhancement of quantal transmitter release and mediatophore expression by cyclic AMP in fibroblasts loaded with acetylcholine

FalkVairant, J, Israel, M, Bruner, J, Stinnakre, J, Meunier, FM, Gaultier, P, Meunier, FA, Lesbats, B, Synguelakis, M, Correges, P and Dunant, Y (1996). Enhancement of quantal transmitter release and mediatophore expression by cyclic AMP in fibroblasts loaded with acetylcholine. Neuroscience, 75 (2), 353-360. doi: 10.1016/0306-4522(96)00260-6

Selective depletion of clear synaptic vesicles and enhanced quantal transmitter release at frog motor nerve endings produced by trachynilysin, a protein toxin isolated from stonefish (Synanceia trachynis) venom

Colasante, C, Meunier, FA, Kreger, AS and Molgo, J (1996). Selective depletion of clear synaptic vesicles and enhanced quantal transmitter release at frog motor nerve endings produced by trachynilysin, a protein toxin isolated from stonefish (Synanceia trachynis) venom. European Journal of Neuroscience, 8 (10), 2149-2156. doi: 10.1111/j.1460-9568.1996.tb00736.x

Expression of the vesicular acetylcholine transporter in mammalian cells

Varoqui, H, Meunier, FM, Meunier, FA, Molgo, J, Berrard, S, Cervini, R, Mallet, J, Israel, M and Diebler, MF (1996). Expression of the vesicular acetylcholine transporter in mammalian cells. Cholinergic Mechanisms: From Molecular Biology to Clinical Significance, 109, 83-95.

Reversed mode Na+-Ca2+ exchange activated by ciguatoxin (CTX-1b) enhances acetylcholine release from Torpedo cholinergic synaptosomes

GaudryTalarmain, YM, Molgo, J, Meunier, FA, Moulian, N and Legrand, AM (1996). Reversed mode Na+-Ca2+ exchange activated by ciguatoxin (CTX-1b) enhances acetylcholine release from Torpedo cholinergic synaptosomes. Sodium-Calcium Exchange, 779, 404-406. doi: 10.1111/j.1749-6632.1996.tb44814.x

Unraveling Munc18/Syntaxin1 nanoscale organisation dynamics in health and disease

Meunier, F. (2019). Unraveling Munc18/Syntaxin1 nanoscale organisation dynamics in health and disease. ISN-ASN Meeting, Montreal, QC, Canada, 4 - 8 August 2019. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.14780

Super-resolving botulinum neurotoxin type A molecules: from surface landing to internalization in synaptic vesicles

Joensuu, Merja, Blum, Ailisa, Mollazade, Mahdie, Lanoue, Vanessa, Padmanabhan, Pranesh, Small, Christopher, Mahrhold, Stefan, Krez, Nadja, Rummel, Andreas and Meunier, Frederic A. (2018). Super-resolving botulinum neurotoxin type A molecules: from surface landing to internalization in synaptic vesicles. TOXINS 2019: Basic Science and Clinical Aspects of Botulinum and Other Neurotoxins, Copenhagen, Denmark, 16-19 January 2019. Kidlington, Oxford, United Kingdom: Pergamon Press. doi: 10.1016/j.toxicon.2018.11.122

Nanoscale imaging of botulinum neurotoxin type a retrograde axonal trafficking

Harper, Callista B., Wang, Tong, Joensuu, Merja, Papadopulos, Andreas and Meunier, Frederic A. (2017). Nanoscale imaging of botulinum neurotoxin type a retrograde axonal trafficking. TOXINS: Basic Science and Clinical Aspects of Botulinum and other Neurotoxins, Madrid, Spain, 18-21 January 2017. Oxford, United Kingdom: Pergamon Press. doi: 10.1016/j.toxicon.2016.11.106

Control of autophagosome axonal retrograde flux by presynaptic activity unveiled using botulinum neurotoxin type-A

Wang, T., Martin, S., Papadopulos, A., Harper, C., Mavlyutov, T., Niranjan, D., Glass, N., Cooper-White, J., Sibarita, J. -B., Choquet, D., Davletov, B. and Meunier, F. (2015). Control of autophagosome axonal retrograde flux by presynaptic activity unveiled using botulinum neurotoxin type-A. 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns Australia, 23-27 August 2015. Hoboken, NJ United States: Wiley-Blackwell.

PI3K delta inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model

Low, Pei Ching (Regine), Manzanero, Silvia, Narayana, Vinod K., Nguyen, Tam H., Kvaskoff, David, Brennan, Faith H., Ruitenberg, Marc J., Gelderblom, Mathias, Magnus, Tim, Kim, Hyun Ah, Broughton, Brad R. S., Sobey, Christopher G., Vanhaesebroeck, Bart, Stow, Jennifer L., Arumugam, Thiruma V. and Meunier, Frederic A. (2014). PI3K delta inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model. 2nd Annual Meeting of the International-Cytokine-and-Interferon-Society (ICIS), Melbourne, Australia, 26-29 October 2014. London, United Kingdom: Academic Press. doi: 10.1016/j.cyto.2014.07.126

Retrograde trafficking at the presynaptic nerve terminal using bacterial toxins

Martin, Sally, Harper, Callista B. and Meunier, Frederic A. (2012). Retrograde trafficking at the presynaptic nerve terminal using bacterial toxins. 17th World Congress of the International-Society-on-Toxinology (IST)/Venom Week/4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, United States, 8-13 July 2012. Kidlington, Oxford, United Kingdom: Pergamon. doi: 10.1016/j.toxicon.2012.04.130

FINE-TUNING OF NEUROEXOCYTOSIS BY TWO MEMBERS OF THE PI3-KINASE FAMILY: TYPE I PI3KDELTA AND TYPE II PI3K-C2ALPHA

Meunier, F. A., Wen, P. J., Osborne, S. L. and Vanhaesebroeck, B. (2011). FINE-TUNING OF NEUROEXOCYTOSIS BY TWO MEMBERS OF THE PI3-KINASE FAMILY: TYPE I PI3KDELTA AND TYPE II PI3K-C2ALPHA. HOBOKEN: WILEY.

Lipid dynamics in exocytosis

Chasserot-Golaz, S., Coorssen, J. R., Meunier, F. A. and Vitale, N. (2010). Lipid dynamics in exocytosis. 15th International Symposium on Chromaffin Cell Biology, Merida, Mexico, 12-16 November 2009. New York, NY, U.S.A.: Springer New York LLC. doi: 10.1007/s10571-010-9577-x

Noninvasive measurement of intracellular viscoelastic properties

Alvarez-Elizondo, Martha B., Roelofs, Susan H., Meunier, Frederic A., Heckenberg, Norman and Rubinsztein-Dunlop, Halina (2008). Noninvasive measurement of intracellular viscoelastic properties. Optical Trapping and Optical Micromanipulation V, San Diego, United States, 10-14 August 2008. Bellingham, WA, United States: S P I E - International Society of Optical Engineering. doi: 10.1117/12.793591

Glycerotoxin and the regulation of neurotransmitter release

Meunier, FA, Ragnarsson, L, Proctor, D, Feng, ZP, Molgo, J, Zamponi, GW and Schiavo, G (2005). Glycerotoxin and the regulation of neurotransmitter release. 20th Biennial Meeting of the International-Society-for-Neurochemistry/European-Society-for-Neurochemistry, Innsbruck Austria, Aug 21-26, 2005. OXFORD: BLACKWELL PUBLISHING.

Glycerotoxin stimulates neurosecretion by up-regulating N-type Ca2+ channel activity

Schiavo, G, Meunier, FA, Feng, ZP, Molgo, J and Zamponi, GW (2004). Glycerotoxin stimulates neurosecretion by up-regulating N-type Ca2+ channel activity. 6th Biennial Meeting of the Asian-Pacific-Society-for-Neurochemistry, Hong Kong Peoples R China, Feb 04-07, 2004. OXFORD: BLACKWELL PUBLISHING LTD.

Class II PI3-kinase C2 alpha is essential for ATP-dependent printing of neurosecretory granule exocytosis

Meunier, F. A., Cooke, F. T., Osborne, S. L., Hammond, G., Domin, J., Parker, P. J. and Schiavo, G. (2004). Class II PI3-kinase C2 alpha is essential for ATP-dependent printing of neurosecretory granule exocytosis. 58th Conference of the Society-of-Nutrition-Physiology, Gottingen, Germany, 9-11 March, 2004. Baltimore, MD: Baltimore, MD.

Glycerotoxin stimulates neurosecretion by up-regulating N-type calcium channel activity

Schiavo, G, Meunier, FA, Feng, ZP, Zamponi, GW and Molgo, J (2003). Glycerotoxin stimulates neurosecretion by up-regulating N-type calcium channel activity. Joint Meeting of the International-Society-for-Neurochemistry/Asian-Pacific-Society-for-Neurochemistry, Wanchai Peoples R China, Aug 03-08, 2003. OXFORD: BLACKWELL PUBLISHING LTD.

Synapse remodelling after neuroparalysis due to cleavage of SNAREs by botlulinum toxins

Lisk, G, Meunier, FA, Poran, PO, Mohammed, N, de Puva, A and Dolly, JO (2001). Synapse remodelling after neuroparalysis due to cleavage of SNAREs by botlulinum toxins. CLARE: ELSEVIER SCI IRELAND LTD.

Trachynilysin, a stonefish protein that affects neurotransmitter release

Meunier, FA, Mattei, C, Colasante, C, Chameau, P, Ouanounou, G, Thieffry, M, Ushkaryov, YA, Dolly, JO, Kreger, AS and Molgo, J (2001). Trachynilysin, a stonefish protein that affects neurotransmitter release. OXFORD: BLACKWELL SCIENCE LTD.

Functional repair of motor endplates after botulinum neurotoxin type A poisoning: Biphasic switch of synaptic activity between nerve sprouts and their parent terminals

de Paiva, A, Meunier, FA, Molgo, J, Aoki, KR and Dolly, JO (1999). Functional repair of motor endplates after botulinum neurotoxin type A poisoning: Biphasic switch of synaptic activity between nerve sprouts and their parent terminals. doi: 10.1073/pnas.96.6.3200

alpha-Latrotoxin stimulates vesicle exocytosis via latrophilin- and PLC-mediated coupling of external and stored Ca-2 and induces Ca2+-independent membrane pores

Davletov, BA, Ashton, AC, Meunier, FA, Matsushita, H, Hirst, WD, Dolly, JO and Ushkarvov, YA (1998). alpha-Latrotoxin stimulates vesicle exocytosis via latrophilin- and PLC-mediated coupling of external and stored Ca-2 and induces Ca2+-independent membrane pores. OXFORD: BLACKWELL SCIENCE LTD.

Quantal transmitter release at botulinum-treated vertebrate neuromuscular junctions

Molgo, J, Meunier, FA and Sellin, LC (1997). Quantal transmitter release at botulinum-treated vertebrate neuromuscular junctions. 11th Meeting of the European-Society-for-Neurochemistry, Groningen Netherlands, Jun 15-20, 1996. NEW YORK: PLENUM PRESS DIV PLENUM PUBLISHING CORP.

Upregulation of calcitonin gene-related peptide at mouse motor nerve terminals poisoned with botulinum type-A toxin

Meunier, Frédéric A., Colasante, Cesare, Faille, Lucette, Gastard, Myriam and Molgó, Jordi (1996). Upregulation of calcitonin gene-related peptide at mouse motor nerve terminals poisoned with botulinum type-A toxin.

Expression of the vesicular acetylcholine transporter in mammalian cells

Varoqui, H., Meunier, F. M., Meunier, F. A., Molgo, J., Berrard, S., Cervini, R., Mallet, J., Israel, M. and Diebler, M. F. (1996). Expression of the vesicular acetylcholine transporter in mammalian cells. Elsevier B.V..

Quantal transmitter release at botulinum-treated vertebrate neuromuscular junctions.

Molgo, J, Meunier, FA and Sellin, LC (1996). Quantal transmitter release at botulinum-treated vertebrate neuromuscular junctions.. 11th Meeting of the European-Society-for-Neurochemistry, Groningen Netherlands, Jun 15-20, 1996. NEW YORK: PLENUM PRESS DIV PLENUM PUBLISHING CORP.

Dynamin1 long- and short-tail isoforms exploit distinct recruitment and spatial patterns to form endocytic nanoclusters

Gormal, Rachel, Jiang, Anmin, Meunier, Frederic, Jiang, Anmin, Longfield, Shanley, Bouquet, Mahe and Kudo, Kye (2024). Dynamin1 long- and short-tail isoforms exploit distinct recruitment and spatial patterns to form endocytic nanoclusters. The University of Queensland. (Dataset) doi: 10.48610/5d9371d

Longfield et al_2024_Synapsin

Meunier, Frederic, Bouquet, Mahe and Longfield, Shanley (2024). Longfield et al_2024_Synapsin. The University of Queensland. (Dataset) doi: 10.48610/be3832e

BoNT/A binding and endocytosis in primary neurons

Joensuu, Merja and Meunier, Frederic (2023). BoNT/A binding and endocytosis in primary neurons. The University of Queensland. (Dataset) doi: 10.48610/06039ff

Longield et al_2023_NatComm_Raw

Gormal, Rachel, Meunier, Frederic, Martinez-Marmol, Ramon, Mollazade, Mahdie, Wallis, Tristan, Joensuu, Merja, Sanders, Shanley and Small, Christopher (2023). Longield et al_2023_NatComm_Raw. The University of Queensland. (Dataset) doi: 10.48610/a9c9def

Syt1-SV2A nanoclustering during SV recycling

Gormal, Rachel, Meunier, Frederic, Small, Christopher, Yak, Nyakuoy, McCann, Alex and Jiang, Anmin (2022). Syt1-SV2A nanoclustering during SV recycling. The University of Queensland. (Dataset) doi: 10.48610/179a9a8

Rat auditory fear conditioning quantified free fatty acid and phospholipid abundance data

Wallis, Tristan P. , Venkatesh, Bharat G. , Narayana, Vinod K. , Kvaskoff, David, Ho, Alan , Sullivan, Robert K. , Windels, François , Sah, Pankaj and Meunier, Frédéric A. (2021). Rat auditory fear conditioning quantified free fatty acid and phospholipid abundance data. The University of Queensland. (Dataset) doi: 10.14264/12793dc